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Development of ocular disease in patients with mucous membrane pemphigoid involving the oral mucosa.

Publication ,  Journal Article
Higgins, GT; Allan, RB; Hall, R; Field, EA; Kaye, SB
Published in: Br J Ophthalmol
August 2006

AIM: To determine the rate of development of ocular disease in patients presenting with mucous membrane pemphigoid (MMP) involving their oral mucosa. METHODS: Diagnosis of oral MMP was made on the basis of clinical signs, histology, and direct and indirect immunofluorescence. Age, race, sex, age at diagnosis, progression of eye signs, duration of follow up, and time to progression of ocular disease were recorded. RESULTS: 30 patients with established oral MMP were reviewed. The mean age at diagnosis was 65.2 years (range 46-84 years) and 16/30 (53%) were male. At initial ocular review nine (30%) patients showed ocular signs of pemphigoid, of whom two had mild (IIA IIIB), four moderate (IIB IIIC), and three severe (IIC IIID) disease. The mean interval between diagnosis of oral MMP and first ophthalmic review was 19.3 months (range 0-144). Over the period of follow up two (7%) patients developed ocular disease at 19 months and 48 months, respectively, despite having had no evidence of ocular involvement at presentation. In total, 11 (37%) patients with oral disease eventually showed ocular disease with a calculated incidence rate for the development of ocular disease of 0.03 per person year over 5 years. CONCLUSIONS: MMP may affect different tissues at different stages, often separated by many years. Patients with MMP involving their oral mucosa are at significant risk of developing ocular disease and should remain under ophthalmic review.

Duke Scholars

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

August 2006

Volume

90

Issue

8

Start / End Page

964 / 967

Location

England

Related Subject Headings

  • Time Factors
  • Severity of Illness Index
  • Pemphigoid, Benign Mucous Membrane
  • Ophthalmology & Optometry
  • Mouth Mucosa
  • Mouth Diseases
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Higgins, G. T., Allan, R. B., Hall, R., Field, E. A., & Kaye, S. B. (2006). Development of ocular disease in patients with mucous membrane pemphigoid involving the oral mucosa. Br J Ophthalmol, 90(8), 964–967. https://doi.org/10.1136/bjo.2006.092528
Higgins, G. T., R. B. Allan, R. Hall, E. A. Field, and S. B. Kaye. “Development of ocular disease in patients with mucous membrane pemphigoid involving the oral mucosa.Br J Ophthalmol 90, no. 8 (August 2006): 964–67. https://doi.org/10.1136/bjo.2006.092528.
Higgins GT, Allan RB, Hall R, Field EA, Kaye SB. Development of ocular disease in patients with mucous membrane pemphigoid involving the oral mucosa. Br J Ophthalmol. 2006 Aug;90(8):964–7.
Higgins, G. T., et al. “Development of ocular disease in patients with mucous membrane pemphigoid involving the oral mucosa.Br J Ophthalmol, vol. 90, no. 8, Aug. 2006, pp. 964–67. Pubmed, doi:10.1136/bjo.2006.092528.
Higgins GT, Allan RB, Hall R, Field EA, Kaye SB. Development of ocular disease in patients with mucous membrane pemphigoid involving the oral mucosa. Br J Ophthalmol. 2006 Aug;90(8):964–967.

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

August 2006

Volume

90

Issue

8

Start / End Page

964 / 967

Location

England

Related Subject Headings

  • Time Factors
  • Severity of Illness Index
  • Pemphigoid, Benign Mucous Membrane
  • Ophthalmology & Optometry
  • Mouth Mucosa
  • Mouth Diseases
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies