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Tissue-Resident Macrophages in Fungal Infections.

Publication ,  Journal Article
Xu, S; Shinohara, ML
Published in: Front Immunol
2017

Invasive fungal infections result in high morbidity and mortality. Host organs targeted by fungal pathogens vary depending on the route of infection and fungal species encountered. Cryptococcus neoformans infects the respiratory tract and disseminates throughout the central nervous system. Candida albicans infects mucosal tissues and the skin, and systemic Candida infection in rodents has a tropism to the kidney. Aspergillus fumigatus reaches distal areas of the lung once inhaled by the host. Across different tissues in naïve hosts, tissue-resident macrophages (TRMs) are one of the most populous cells of the innate immune system. Although they function to maintain homeostasis in a tissue-specific manner during steady state, TRMs may function as the first line of defense against invading pathogens and may regulate host immune responses. Thus, in any organs, TRMs are uniquely positioned and specifically programmed to function. This article reviews the current understanding of the roles of TRMs during major fungal infections.

Duke Scholars

Published In

Front Immunol

DOI

ISSN

1664-3224

Publication Date

2017

Volume

8

Start / End Page

1798

Location

Switzerland

Related Subject Headings

  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Xu, S., & Shinohara, M. L. (2017). Tissue-Resident Macrophages in Fungal Infections. Front Immunol, 8, 1798. https://doi.org/10.3389/fimmu.2017.01798
Xu, Shengjie, and Mari L. Shinohara. “Tissue-Resident Macrophages in Fungal Infections.Front Immunol 8 (2017): 1798. https://doi.org/10.3389/fimmu.2017.01798.
Xu S, Shinohara ML. Tissue-Resident Macrophages in Fungal Infections. Front Immunol. 2017;8:1798.
Xu, Shengjie, and Mari L. Shinohara. “Tissue-Resident Macrophages in Fungal Infections.Front Immunol, vol. 8, 2017, p. 1798. Pubmed, doi:10.3389/fimmu.2017.01798.
Xu S, Shinohara ML. Tissue-Resident Macrophages in Fungal Infections. Front Immunol. 2017;8:1798.

Published In

Front Immunol

DOI

ISSN

1664-3224

Publication Date

2017

Volume

8

Start / End Page

1798

Location

Switzerland

Related Subject Headings

  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 1107 Immunology