The importance of dose in isocarboxazid therapy.
Publication
, Journal Article
Davidson, J; Turnbull, C
Published in: J Clin Psychiatry
July 1984
Little information is available on the effectiveness and safety of particular doses of isocarboxazid. In a study using isocarboxazid doses of 30 and 50 mg/day in depressed inpatients, the higher dose was well tolerated and did not result in any greater toxicity than the 30 mg dose. Significantly greater elevation of plasma serotonin (Week 2) and platelet MAO inhibition were seen with 50 mg/day. In nonmelancholic depressions, 50 mg proved to be more effective than 30 mg in symptoms of depression and anxiety. However, this did not apply to the vegetative-physiologic symptoms of depression.
Duke Scholars
Published In
J Clin Psychiatry
ISSN
0160-6689
Publication Date
July 1984
Volume
45
Issue
7 Pt 2
Start / End Page
49 / 52
Location
United States
Related Subject Headings
- Serotonin
- Psychiatry
- Psychiatric Status Rating Scales
- Monoamine Oxidase
- Liver
- Isocarboxazid
- Hypotension, Orthostatic
- Humans
- Drug Administration Schedule
- Dose-Response Relationship, Drug
Citation
APA
Chicago
ICMJE
MLA
NLM
Davidson, J., & Turnbull, C. (1984). The importance of dose in isocarboxazid therapy. J Clin Psychiatry, 45(7 Pt 2), 49–52.
Davidson, J., and C. Turnbull. “The importance of dose in isocarboxazid therapy.” J Clin Psychiatry 45, no. 7 Pt 2 (July 1984): 49–52.
Davidson J, Turnbull C. The importance of dose in isocarboxazid therapy. J Clin Psychiatry. 1984 Jul;45(7 Pt 2):49–52.
Davidson, J., and C. Turnbull. “The importance of dose in isocarboxazid therapy.” J Clin Psychiatry, vol. 45, no. 7 Pt 2, July 1984, pp. 49–52.
Davidson J, Turnbull C. The importance of dose in isocarboxazid therapy. J Clin Psychiatry. 1984 Jul;45(7 Pt 2):49–52.
Published In
J Clin Psychiatry
ISSN
0160-6689
Publication Date
July 1984
Volume
45
Issue
7 Pt 2
Start / End Page
49 / 52
Location
United States
Related Subject Headings
- Serotonin
- Psychiatry
- Psychiatric Status Rating Scales
- Monoamine Oxidase
- Liver
- Isocarboxazid
- Hypotension, Orthostatic
- Humans
- Drug Administration Schedule
- Dose-Response Relationship, Drug