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Relationship between response to phenelzine and MAO inhibition in a clinical trial of phenelzine, amitriptyline and placebo.

Publication ,  Journal Article
Raft, D; Davidson, J; Wasik, J; Mattox, A
Published in: Neuropsychobiology
1981

This report examines the hypothesis that for phenelzine to be more effective than placebo it is necessary to achieve at least 80% inhibition of platelet MAO activity. This hypothesis was examined in the context of a double-blind comparison of phenelzine, amitriptyline and placebo in depressed patients. When phenelzine became significantly more effective than placebo at 4 weeks, the average MAO inhibition was 85%. By the 5th week, with MAO inhibition greater than 90%, phenelzine was significantly more effective than amitriptyline. A highly significant correlation was noted between improvement and MAO inhibition within the phenelzine group.

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Published In

Neuropsychobiology

DOI

ISSN

0302-282X

Publication Date

1981

Volume

7

Issue

3

Start / End Page

122 / 126

Location

Switzerland

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Phenelzine
  • Monoamine Oxidase
  • Humans
  • Depressive Disorder
  • Blood Platelets
  • Amitriptyline
  • 5202 Biological psychology
  • 4203 Health services and systems
 

Citation

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Raft, D., Davidson, J., Wasik, J., & Mattox, A. (1981). Relationship between response to phenelzine and MAO inhibition in a clinical trial of phenelzine, amitriptyline and placebo. Neuropsychobiology, 7(3), 122–126. https://doi.org/10.1159/000117841
Raft, D., J. Davidson, J. Wasik, and A. Mattox. “Relationship between response to phenelzine and MAO inhibition in a clinical trial of phenelzine, amitriptyline and placebo.Neuropsychobiology 7, no. 3 (1981): 122–26. https://doi.org/10.1159/000117841.
Raft, D., et al. “Relationship between response to phenelzine and MAO inhibition in a clinical trial of phenelzine, amitriptyline and placebo.Neuropsychobiology, vol. 7, no. 3, 1981, pp. 122–26. Pubmed, doi:10.1159/000117841.
Journal cover image

Published In

Neuropsychobiology

DOI

ISSN

0302-282X

Publication Date

1981

Volume

7

Issue

3

Start / End Page

122 / 126

Location

Switzerland

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Phenelzine
  • Monoamine Oxidase
  • Humans
  • Depressive Disorder
  • Blood Platelets
  • Amitriptyline
  • 5202 Biological psychology
  • 4203 Health services and systems