Acetylation phenotype, platelet monoamine oxidase inhibition, and the effectiveness of phenelzine in depression.
Publication
, Journal Article
Davidson, J; McLeod, MN; Blum, MR
Published in: Am J Psychiatry
April 1978
The authors treated 16 depressed patients with up to 90 mg/day of phenelzine. After acetylation phenotype was determined and platelet monoamine oxidase (MAO) activity measured, no significant relationship was observed between clinical improvement and acetylation phenotype or between MAO inhibition and acetylation. Discrepant findings regarding acetylation phenotype and the effects of phenelzine are discussed. The authors do not recommend a sulfamethazine phenotype test as a predictor of outcome for phenelzine.
Duke Scholars
Published In
Am J Psychiatry
DOI
ISSN
0002-953X
Publication Date
April 1978
Volume
135
Issue
4
Start / End Page
467 / 469
Location
United States
Related Subject Headings
- Sulfamethazine
- Psychiatry
- Phenotype
- Phenelzine
- Monoamine Oxidase
- Humans
- Drug Evaluation
- Dose-Response Relationship, Drug
- Depression
- Clinical Trials as Topic
Citation
APA
Chicago
ICMJE
MLA
NLM
Davidson, J., McLeod, M. N., & Blum, M. R. (1978). Acetylation phenotype, platelet monoamine oxidase inhibition, and the effectiveness of phenelzine in depression. Am J Psychiatry, 135(4), 467–469. https://doi.org/10.1176/ajp.135.4.467
Davidson, J., M. N. McLeod, and M. R. Blum. “Acetylation phenotype, platelet monoamine oxidase inhibition, and the effectiveness of phenelzine in depression.” Am J Psychiatry 135, no. 4 (April 1978): 467–69. https://doi.org/10.1176/ajp.135.4.467.
Davidson J, McLeod MN, Blum MR. Acetylation phenotype, platelet monoamine oxidase inhibition, and the effectiveness of phenelzine in depression. Am J Psychiatry. 1978 Apr;135(4):467–9.
Davidson, J., et al. “Acetylation phenotype, platelet monoamine oxidase inhibition, and the effectiveness of phenelzine in depression.” Am J Psychiatry, vol. 135, no. 4, Apr. 1978, pp. 467–69. Pubmed, doi:10.1176/ajp.135.4.467.
Davidson J, McLeod MN, Blum MR. Acetylation phenotype, platelet monoamine oxidase inhibition, and the effectiveness of phenelzine in depression. Am J Psychiatry. 1978 Apr;135(4):467–469.
Published In
Am J Psychiatry
DOI
ISSN
0002-953X
Publication Date
April 1978
Volume
135
Issue
4
Start / End Page
467 / 469
Location
United States
Related Subject Headings
- Sulfamethazine
- Psychiatry
- Phenotype
- Phenelzine
- Monoamine Oxidase
- Humans
- Drug Evaluation
- Dose-Response Relationship, Drug
- Depression
- Clinical Trials as Topic