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The effects of isocarboxazid on blood pressure and pulse.

Publication ,  Journal Article
Davidson, J; Turnbull, CD
Published in: J Clin Psychopharmacol
June 1986

In a fixed-dose inpatient study, isocarboxazid produced a dose-related lowering of systolic blood pressure at weeks 2 and 4. Systolic blood pressure was also lowered by the drug in a placebo-controlled outpatient study. The magnitude of these reductions was considerable, reaching an average of 14.6 mm in inpatients who received a 50-mg dose, and 18.7 mm in outpatients. There was no evidence for a dose-related orthostatic effect, and greater orthostasis relative to placebo was found only at week 3 in the outpatient study. Significant bradycardia was produced by isocarboxazid in outpatients at weeks 2, 3, and 4 relative to placebo, but no dose-related effect was found among inpatients. Inpatients with a baseline systolic orthostatic drop of greater than or equal to 10 mm showed a significantly better response to isocarboxazid than did those with an orthostasis of less than 10 mm. The theoretical significance of these findings is discussed.

Duke Scholars

Published In

J Clin Psychopharmacol

ISSN

0271-0749

Publication Date

June 1986

Volume

6

Issue

3

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Time Factors
  • Pulse
  • Psychiatry
  • Posture
  • Middle Aged
  • Male
  • Isocarboxazid
  • Humans
  • Female
  • Double-Blind Method
 

Citation

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Davidson, J., & Turnbull, C. D. (1986). The effects of isocarboxazid on blood pressure and pulse. J Clin Psychopharmacol, 6(3), 139–143.
Davidson, J., and C. D. Turnbull. “The effects of isocarboxazid on blood pressure and pulse.J Clin Psychopharmacol 6, no. 3 (June 1986): 139–43.
Davidson J, Turnbull CD. The effects of isocarboxazid on blood pressure and pulse. J Clin Psychopharmacol. 1986 Jun;6(3):139–43.
Davidson, J., and C. D. Turnbull. “The effects of isocarboxazid on blood pressure and pulse.J Clin Psychopharmacol, vol. 6, no. 3, June 1986, pp. 139–43.
Davidson J, Turnbull CD. The effects of isocarboxazid on blood pressure and pulse. J Clin Psychopharmacol. 1986 Jun;6(3):139–143.

Published In

J Clin Psychopharmacol

ISSN

0271-0749

Publication Date

June 1986

Volume

6

Issue

3

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Time Factors
  • Pulse
  • Psychiatry
  • Posture
  • Middle Aged
  • Male
  • Isocarboxazid
  • Humans
  • Female
  • Double-Blind Method