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Neurobiological mechanisms in generalized anxiety disorder.

Publication ,  Conference
Nutt, DJ
Published in: J Clin Psychiatry
2001

Generalized anxiety disorder (GAD) is a common and serious disorder. Despite this fact, there is no clear understanding of the exact neurobiological changes underlying the condition. To date, there are few studies of neurobiological function in patients with GAD, and only limited comparative data with depression are available. Advances in neuroanatomical imaging techniques are beginning to allow detailed study of regional blood flow and metabolism and may offer insights into the specific regions of the brain involved in GAD. Investigations into neurotransmitter dysfunction have implicated the gamma-aminobutyric acid/benzodiazepine, serotonergic, and noradrenergic systems in this disorder. Variations in sleep patterns have also been assessed and indicate a biological separation from depression.

Duke Scholars

Published In

J Clin Psychiatry

ISSN

0160-6689

Publication Date

2001

Volume

62 Suppl 11

Start / End Page

22 / 27

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Sleep Wake Disorders
  • Sleep
  • Serotonin
  • Regional Blood Flow
  • Receptors, Serotonin
  • Receptors, GABA
  • Receptors, Adrenergic
  • Psychiatry
  • Norepinephrine
 

Citation

APA
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ICMJE
MLA
NLM
Nutt, D. J. (2001). Neurobiological mechanisms in generalized anxiety disorder. In J Clin Psychiatry (Vol. 62 Suppl 11, pp. 22–27). United States.
Nutt, D. J. “Neurobiological mechanisms in generalized anxiety disorder.” In J Clin Psychiatry, 62 Suppl 11:22–27, 2001.
Nutt DJ. Neurobiological mechanisms in generalized anxiety disorder. In: J Clin Psychiatry. 2001. p. 22–7.
Nutt, D. J. “Neurobiological mechanisms in generalized anxiety disorder.J Clin Psychiatry, vol. 62 Suppl 11, 2001, pp. 22–27.
Nutt DJ. Neurobiological mechanisms in generalized anxiety disorder. J Clin Psychiatry. 2001. p. 22–27.

Published In

J Clin Psychiatry

ISSN

0160-6689

Publication Date

2001

Volume

62 Suppl 11

Start / End Page

22 / 27

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Sleep Wake Disorders
  • Sleep
  • Serotonin
  • Regional Blood Flow
  • Receptors, Serotonin
  • Receptors, GABA
  • Receptors, Adrenergic
  • Psychiatry
  • Norepinephrine