Skip to main content

Single case study. Complementary effects of phenelzine and psychotherapy in long term treatment of depression.

Publication ,  Journal Article
Davidson, J; Raft, D; Freeman, C
Published in: J Nerv Ment Dis
October 1979

A case report is described wherein the monoamine oxidase inhibitor phenelzine was administered for 10 months at different doses. Drug treatment in the initial part of the study was double blind. Weekly psychotherapy was instituted at the point of symptomatic recovery. At a reduced dose, in month 3, the patient experienced a relapse in depression. While platelet monoamine oxidase inhibition was greater than 80 per cent the patient was well, but at the point of relapse, inhibition was 14 per cent. Clinical ratings at relapse (Beck and SCL-90 scales) revealed greater readiness by the patient to report psychological discomfort compared with the original interview. The combined effects of psychotherapy and pharmacotherapy were felt to be responsible for this change. However, psychotherapy in this form and duration did not prevent relapse, which depended upon maintaining an adequate dose of phenelzine.

Duke Scholars

Published In

J Nerv Ment Dis

DOI

ISSN

0022-3018

Publication Date

October 1979

Volume

167

Issue

10

Start / End Page

632 / 634

Location

United States

Related Subject Headings

  • Recurrence
  • Psychotherapy
  • Psychiatry
  • Phenelzine
  • Monoamine Oxidase
  • Long-Term Care
  • Humans
  • Female
  • Depression
  • Blood Platelets
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davidson, J., Raft, D., & Freeman, C. (1979). Single case study. Complementary effects of phenelzine and psychotherapy in long term treatment of depression. J Nerv Ment Dis, 167(10), 632–634. https://doi.org/10.1097/00005053-197910000-00008
Davidson, J., D. Raft, and C. Freeman. “Single case study. Complementary effects of phenelzine and psychotherapy in long term treatment of depression.J Nerv Ment Dis 167, no. 10 (October 1979): 632–34. https://doi.org/10.1097/00005053-197910000-00008.
Davidson J, Raft D, Freeman C. Single case study. Complementary effects of phenelzine and psychotherapy in long term treatment of depression. J Nerv Ment Dis. 1979 Oct;167(10):632–4.
Davidson, J., et al. “Single case study. Complementary effects of phenelzine and psychotherapy in long term treatment of depression.J Nerv Ment Dis, vol. 167, no. 10, Oct. 1979, pp. 632–34. Pubmed, doi:10.1097/00005053-197910000-00008.
Davidson J, Raft D, Freeman C. Single case study. Complementary effects of phenelzine and psychotherapy in long term treatment of depression. J Nerv Ment Dis. 1979 Oct;167(10):632–634.

Published In

J Nerv Ment Dis

DOI

ISSN

0022-3018

Publication Date

October 1979

Volume

167

Issue

10

Start / End Page

632 / 634

Location

United States

Related Subject Headings

  • Recurrence
  • Psychotherapy
  • Psychiatry
  • Phenelzine
  • Monoamine Oxidase
  • Long-Term Care
  • Humans
  • Female
  • Depression
  • Blood Platelets