Are Lethal Alleles Too Abundant in Humans?
Publication
, Journal Article
Ballinger, MA; Noor, MAF
Published in: Trends in genetics : TIG
February 2018
Across species, many individuals carry one or more recessive lethal alleles, posing an evolutionary conundrum for their persistence. Using a population genomic approach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and found that, while appearing more common than expected, most may nonetheless persist at frequencies predicted by mutation-selection balance.
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Published In
Trends in genetics : TIG
DOI
ISSN
0168-9525
Publication Date
February 2018
Volume
34
Issue
2
Start / End Page
87 / 89
Related Subject Headings
- Mutation
- Humans
- Genes, Recessive
- Genes, Lethal
- Developmental Biology
- Alleles
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Ballinger, M. A., & Noor, M. A. F. (2018). Are Lethal Alleles Too Abundant in Humans? Trends in Genetics : TIG, 34(2), 87–89. https://doi.org/10.1016/j.tig.2017.12.013
Ballinger, Mallory A., and Mohamed A. F. Noor. “Are Lethal Alleles Too Abundant in Humans?” Trends in Genetics : TIG 34, no. 2 (February 2018): 87–89. https://doi.org/10.1016/j.tig.2017.12.013.
Ballinger MA, Noor MAF. Are Lethal Alleles Too Abundant in Humans? Trends in genetics : TIG. 2018 Feb;34(2):87–9.
Ballinger, Mallory A., and Mohamed A. F. Noor. “Are Lethal Alleles Too Abundant in Humans?” Trends in Genetics : TIG, vol. 34, no. 2, Feb. 2018, pp. 87–89. Epmc, doi:10.1016/j.tig.2017.12.013.
Ballinger MA, Noor MAF. Are Lethal Alleles Too Abundant in Humans? Trends in genetics : TIG. 2018 Feb;34(2):87–89.
Published In
Trends in genetics : TIG
DOI
ISSN
0168-9525
Publication Date
February 2018
Volume
34
Issue
2
Start / End Page
87 / 89
Related Subject Headings
- Mutation
- Humans
- Genes, Recessive
- Genes, Lethal
- Developmental Biology
- Alleles
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences