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Are Lethal Alleles Too Abundant in Humans?

Publication ,  Journal Article
Ballinger, MA; Noor, MAF
Published in: Trends in genetics : TIG
February 2018

Across species, many individuals carry one or more recessive lethal alleles, posing an evolutionary conundrum for their persistence. Using a population genomic approach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and found that, while appearing more common than expected, most may nonetheless persist at frequencies predicted by mutation-selection balance.

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Published In

Trends in genetics : TIG

DOI

ISSN

0168-9525

Publication Date

February 2018

Volume

34

Issue

2

Start / End Page

87 / 89

Related Subject Headings

  • Mutation
  • Humans
  • Genes, Recessive
  • Genes, Lethal
  • Developmental Biology
  • Alleles
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

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ICMJE
MLA
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Ballinger, M. A., & Noor, M. A. F. (2018). Are Lethal Alleles Too Abundant in Humans? Trends in Genetics : TIG, 34(2), 87–89. https://doi.org/10.1016/j.tig.2017.12.013
Ballinger, Mallory A., and Mohamed A. F. Noor. “Are Lethal Alleles Too Abundant in Humans?Trends in Genetics : TIG 34, no. 2 (February 2018): 87–89. https://doi.org/10.1016/j.tig.2017.12.013.
Ballinger MA, Noor MAF. Are Lethal Alleles Too Abundant in Humans? Trends in genetics : TIG. 2018 Feb;34(2):87–9.
Ballinger, Mallory A., and Mohamed A. F. Noor. “Are Lethal Alleles Too Abundant in Humans?Trends in Genetics : TIG, vol. 34, no. 2, Feb. 2018, pp. 87–89. Epmc, doi:10.1016/j.tig.2017.12.013.
Ballinger MA, Noor MAF. Are Lethal Alleles Too Abundant in Humans? Trends in genetics : TIG. 2018 Feb;34(2):87–89.
Journal cover image

Published In

Trends in genetics : TIG

DOI

ISSN

0168-9525

Publication Date

February 2018

Volume

34

Issue

2

Start / End Page

87 / 89

Related Subject Headings

  • Mutation
  • Humans
  • Genes, Recessive
  • Genes, Lethal
  • Developmental Biology
  • Alleles
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences