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Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control.

Publication ,  Journal Article
Patel, PR; Kirkpatrick, J; Salama, JK; Nelson, J; Broadwater, G; Allen, K; Clough, R; Yin, F-F; Wang, Z; Chang, Z; Kelsey, C; Ghafoori, AP
Published in: J Radiosurg SBRT
2014

We analyzed factors associated with inferior local control following stereotactic ablative body radiotherapy (SABR) for palliation of metastases. We reviewed records of patients receiving SABR for metastases at Duke University from 2006-2010. Biologically effective dose (BED) was calculated using the linear-quadratic model. Toxicity was assessed by CTCAE v4.0. The Kaplan-Meier method was used to estimate overall survival (OS) and local control (LC) within subgroups (primary or salvage SABR). Univariate (UVA) and multivariate (MVA) regression analysis was used. Fifty and 33 patients received primary and salvage SABR, respectively. 105 lesions were treated (52 spine, 27 lung, 7 liver, 11 other); 67 primary SABR and 38 salvage. Median clinical follow-up was 11.1 months and 10.3 months with imaging of the treated lesion. One patient received SABR x3 and died from toxicity. 88% of symptomatic patients improved after SABR. 1-year LC and OS were 83% and 50%, respectively. Primary SABR had higher BED and was associated with improved LC on UVA (HR 3.0, p=0.01) and MVA (p=0.02); treatment site and histology were not. SABR results in effective palliation of metastases regardless of prior treatment. In the absence of prior EBRT, SABR can be delivered with higher BED and may be associated with better outcomes.

Duke Scholars

Published In

J Radiosurg SBRT

ISSN

2156-4639

Publication Date

2014

Volume

3

Issue

2

Start / End Page

123 / 129

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, P. R., Kirkpatrick, J., Salama, J. K., Nelson, J., Broadwater, G., Allen, K., … Ghafoori, A. P. (2014). Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control. J Radiosurg SBRT, 3(2), 123–129.
Patel, Pretesh R., John Kirkpatrick, Joseph K. Salama, John Nelson, Gloria Broadwater, Karen Allen, Robert Clough, et al. “Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control.J Radiosurg SBRT 3, no. 2 (2014): 123–29.
Patel PR, Kirkpatrick J, Salama JK, Nelson J, Broadwater G, Allen K, et al. Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control. J Radiosurg SBRT. 2014;3(2):123–9.
Patel, Pretesh R., et al. “Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control.J Radiosurg SBRT, vol. 3, no. 2, 2014, pp. 123–29.
Patel PR, Kirkpatrick J, Salama JK, Nelson J, Broadwater G, Allen K, Clough R, Yin F-F, Wang Z, Chang Z, Kelsey C, Ghafoori AP. Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control. J Radiosurg SBRT. 2014;3(2):123–129.

Published In

J Radiosurg SBRT

ISSN

2156-4639

Publication Date

2014

Volume

3

Issue

2

Start / End Page

123 / 129

Location

United States