Skip to main content
Journal cover image

The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen.

Publication ,  Journal Article
George, S; McBurney, A; Ward, JW
Published in: Eur J Clin Pharmacol
1986

A 250 mg tablet of timegadine was given twice daily for 15 days to 13 healthy volunteers. On Day 16 a single morning dose of timegadine was supplemented by two 200 mg tablets of a proprietary brand of ibuprofen. Serum concentrations of timegadine were measured by high pressure liquid chromatography, and steady state was achieved between Days 5 and 8. Serum concentrations of two metabolites of timegadine, MI and MII were measured by thin layer chromatography by Leo Pharmaceutical Products, Denmark. Ibuprofen did not significantly affect the serum half-time of timegadine, but did reduce the maximum measured serum timegadine concentration, the area under the serum concentration versus time curve and the time to achieve maximum measured serum concentration. Serum liver enzymes remained within the normal ranges and there were no changes in hepatic microsomal enzyme activity as assessed by urinary excretion of D-glucaric acid.

Duke Scholars

Published In

Eur J Clin Pharmacol

DOI

ISSN

0031-6970

Publication Date

1986

Volume

29

Issue

5

Start / End Page

581 / 586

Location

Germany

Related Subject Headings

  • Pharmacology & Pharmacy
  • Liver Function Tests
  • Liver
  • Kinetics
  • Ibuprofen
  • Humans
  • Half-Life
  • Guanidines
  • Enzyme Induction
  • Drug Interactions
 

Citation

APA
Chicago
ICMJE
MLA
NLM
George, S., McBurney, A., & Ward, J. W. (1986). The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen. Eur J Clin Pharmacol, 29(5), 581–586. https://doi.org/10.1007/BF00635896
George, S., A. McBurney, and J. W. Ward. “The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen.Eur J Clin Pharmacol 29, no. 5 (1986): 581–86. https://doi.org/10.1007/BF00635896.
George, S., et al. “The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen.Eur J Clin Pharmacol, vol. 29, no. 5, 1986, pp. 581–86. Pubmed, doi:10.1007/BF00635896.
Journal cover image

Published In

Eur J Clin Pharmacol

DOI

ISSN

0031-6970

Publication Date

1986

Volume

29

Issue

5

Start / End Page

581 / 586

Location

Germany

Related Subject Headings

  • Pharmacology & Pharmacy
  • Liver Function Tests
  • Liver
  • Kinetics
  • Ibuprofen
  • Humans
  • Half-Life
  • Guanidines
  • Enzyme Induction
  • Drug Interactions