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Tissue plasminogen activator and glaucoma drainage implants

Publication ,  Journal Article
Sidoti, PA; Morinelli, EN; Heuer, DK; Lundy, DC; Lee, PP; Minckler, DS
Published in: Journal of Glaucoma
January 1, 1995

Purpose: The tube lumen of a glaucoma drainage implant is prone to occlusion by a blood or fibrin clot due to its small caliber, relatively low flow rate, and the plasmoid nature of the aqueous humor passing through it in the early postoperative period. The use of tissue plasminogen activator in the management of drainage tube obstruction is described herein. Methods: Two cases of drainage tube obstruction in patients with neovas-cular glaucoma treated with an intracameral injection of tissue plasminogen activator are reported. Results: Resolution of tube obstruction following tissue plasminogen activator administration with spontaneous lowering of the intraocular pressure and bleb formation was achieved in both cases. Differentiation of tube obstruction from other causes of elevated intraocular pressure following installation of glaucoma drainage devices is discussed. Conclusion: The intracameral injection of tissue plasminogen activator may relieve drainage tube obstruction secondary to a blood or fibrin clot, even in the absence of any visible clot covering the proximal tube ostium or within the anterior chamber portion of the tube. This approach should be considered, in selected cases, prior to more invasive surgical revision. © 1995 Lippincott-Raven Publishers.

Duke Scholars

Published In

Journal of Glaucoma

DOI

EISSN

1536-481X

ISSN

1057-0829

Publication Date

January 1, 1995

Volume

4

Issue

4

Start / End Page

258 / 262

Related Subject Headings

  • Ophthalmology & Optometry
  • 1103 Clinical Sciences
 

Citation

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MLA
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Sidoti, P. A., Morinelli, E. N., Heuer, D. K., Lundy, D. C., Lee, P. P., & Minckler, D. S. (1995). Tissue plasminogen activator and glaucoma drainage implants. Journal of Glaucoma, 4(4), 258–262. https://doi.org/10.1097/00061198-199508000-00007
Sidoti, P. A., E. N. Morinelli, D. K. Heuer, D. C. Lundy, P. P. Lee, and D. S. Minckler. “Tissue plasminogen activator and glaucoma drainage implants.” Journal of Glaucoma 4, no. 4 (January 1, 1995): 258–62. https://doi.org/10.1097/00061198-199508000-00007.
Sidoti PA, Morinelli EN, Heuer DK, Lundy DC, Lee PP, Minckler DS. Tissue plasminogen activator and glaucoma drainage implants. Journal of Glaucoma. 1995 Jan 1;4(4):258–62.
Sidoti, P. A., et al. “Tissue plasminogen activator and glaucoma drainage implants.” Journal of Glaucoma, vol. 4, no. 4, Jan. 1995, pp. 258–62. Scopus, doi:10.1097/00061198-199508000-00007.
Sidoti PA, Morinelli EN, Heuer DK, Lundy DC, Lee PP, Minckler DS. Tissue plasminogen activator and glaucoma drainage implants. Journal of Glaucoma. 1995 Jan 1;4(4):258–262.

Published In

Journal of Glaucoma

DOI

EISSN

1536-481X

ISSN

1057-0829

Publication Date

January 1, 1995

Volume

4

Issue

4

Start / End Page

258 / 262

Related Subject Headings

  • Ophthalmology & Optometry
  • 1103 Clinical Sciences