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Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis.

Publication ,  Journal Article
Sergentanis, TN; Economopoulos, KP; Choussein, S; Vlahos, NF
Published in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
February 2011

This meta-analysis aims to examine whether the genotype status of Msp1, Ile462Val, and Thr461Asn polymorphisms in cytochrome P450 1A1 (CYP1A1) is associated with endometrial cancer risk.Eligible case-control studies were identified through search in MEDLINE (end of search: August 2010). Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models.Concerning MspI polymorphism, 8 studies were eligible (1456 cases and 2371 controls); 9 studies were eligible (1889 cases and 3662 controls) for Ile462Val and 6 studies were eligible (1272 cases and 2122 controls) for Thr461Asn. MspI polymorphism was not associated with endometrial cancer risk (for heterozygous TC vs TT carriers: OR = 0.83, 95% confidence interval [CI], 0.59-1.15, random effects; for homozygous CC vs TT carriers: OR = 1.00, 95% CI, 0.55-1.82, fixed effects). Similarly, Ile462Val polymorphism was not associated with endometrial cancer risk (for heterozygous Ile/Val vs Ile/Ile carriers: OR = 1.27, 95% CI, 0.78-2.06, random effects; for homozygous Val/Val vs Ile/Ile carriers: OR = 1.16, 95% CI, 0.48-2.81, fixed effects). Accordingly, Thr461Asn status was not significantly associated with endometrial cancer risk. The same results were reproduced in Caucasians.The 3 examined CYP1A1 genotype polymorphisms do not seem to confer any additional risk for endometrial cancer in Caucasians. Accumulation of further data seems mandatory for future race-specific analyses.

Duke Scholars

Published In

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

DOI

EISSN

1525-1438

ISSN

1048-891X

Publication Date

February 2011

Volume

21

Issue

2

Start / End Page

323 / 331

Related Subject Headings

  • White People
  • Risk
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Endometrial Neoplasms
  • Cytochrome P-450 CYP1A1
  • 3211 Oncology and carcinogenesis
 

Citation

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ICMJE
MLA
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Sergentanis, T. N., Economopoulos, K. P., Choussein, S., & Vlahos, N. F. (2011). Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society, 21(2), 323–331. https://doi.org/10.1097/igc.0b013e31820575c0
Sergentanis, Theodoros N., Konstantinos P. Economopoulos, Souzana Choussein, and Nikos F. Vlahos. “Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis.International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society 21, no. 2 (February 2011): 323–31. https://doi.org/10.1097/igc.0b013e31820575c0.
Sergentanis TN, Economopoulos KP, Choussein S, Vlahos NF. Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2011 Feb;21(2):323–31.
Sergentanis, Theodoros N., et al. “Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis.International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society, vol. 21, no. 2, Feb. 2011, pp. 323–31. Epmc, doi:10.1097/igc.0b013e31820575c0.
Sergentanis TN, Economopoulos KP, Choussein S, Vlahos NF. Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2011 Feb;21(2):323–331.
Journal cover image

Published In

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

DOI

EISSN

1525-1438

ISSN

1048-891X

Publication Date

February 2011

Volume

21

Issue

2

Start / End Page

323 / 331

Related Subject Headings

  • White People
  • Risk
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Endometrial Neoplasms
  • Cytochrome P-450 CYP1A1
  • 3211 Oncology and carcinogenesis