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Evolving Landscape of Clinical Trials in Heart Failure: Patient Populations, Endpoint Selection, and Regions of Enrollment.

Publication ,  Journal Article
Samman Tahhan, A; Vaduganathan, M; Greene, SJ; Okafor, M; Kumar, S; Butler, J
Published in: Curr Heart Fail Rep
February 2018

PURPOSE OF REVIEW: Clinical trial design and execution are evolving as increasingly important considerations with respect to the success of heart failure trials. The current review highlights temporal trends in characteristics of heart failure clinical trials. RECENT FINDINGS: Recent trials in heart failure have required longer recruitment phases, displayed inefficient enrollment rates, increased use of composite and nonfatal endpoints, undergone rapid globalization, and gradually increased focus on heart failure with preserved ejection fraction. Understanding patterns and trends in clinical trial design and execution may inform future planning and conduct of trials of heart failure therapeutics.

Duke Scholars

Published In

Curr Heart Fail Rep

DOI

EISSN

1546-9549

Publication Date

February 2018

Volume

15

Issue

1

Start / End Page

10 / 16

Location

United States

Related Subject Headings

  • Stroke Volume
  • Patient Selection
  • Humans
  • Heart Failure
  • Endpoint Determination
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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ICMJE
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Samman Tahhan, A., Vaduganathan, M., Greene, S. J., Okafor, M., Kumar, S., & Butler, J. (2018). Evolving Landscape of Clinical Trials in Heart Failure: Patient Populations, Endpoint Selection, and Regions of Enrollment. Curr Heart Fail Rep, 15(1), 10–16. https://doi.org/10.1007/s11897-018-0374-z
Samman Tahhan, Ayman, Muthiah Vaduganathan, Stephen J. Greene, Maureen Okafor, Sonali Kumar, and Javed Butler. “Evolving Landscape of Clinical Trials in Heart Failure: Patient Populations, Endpoint Selection, and Regions of Enrollment.Curr Heart Fail Rep 15, no. 1 (February 2018): 10–16. https://doi.org/10.1007/s11897-018-0374-z.
Samman Tahhan A, Vaduganathan M, Greene SJ, Okafor M, Kumar S, Butler J. Evolving Landscape of Clinical Trials in Heart Failure: Patient Populations, Endpoint Selection, and Regions of Enrollment. Curr Heart Fail Rep. 2018 Feb;15(1):10–6.
Samman Tahhan, Ayman, et al. “Evolving Landscape of Clinical Trials in Heart Failure: Patient Populations, Endpoint Selection, and Regions of Enrollment.Curr Heart Fail Rep, vol. 15, no. 1, Feb. 2018, pp. 10–16. Pubmed, doi:10.1007/s11897-018-0374-z.
Samman Tahhan A, Vaduganathan M, Greene SJ, Okafor M, Kumar S, Butler J. Evolving Landscape of Clinical Trials in Heart Failure: Patient Populations, Endpoint Selection, and Regions of Enrollment. Curr Heart Fail Rep. 2018 Feb;15(1):10–16.
Journal cover image

Published In

Curr Heart Fail Rep

DOI

EISSN

1546-9549

Publication Date

February 2018

Volume

15

Issue

1

Start / End Page

10 / 16

Location

United States

Related Subject Headings

  • Stroke Volume
  • Patient Selection
  • Humans
  • Heart Failure
  • Endpoint Determination
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology