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Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma.

Publication ,  Journal Article
Gillis, AM; Sutton, E; Dewitt, KD; Matthay, KK; Weinberg, V; Fisch, BM; Chan, A; Gooding, C; Daldrup-Link, H; Wara, WM; Farmer, DL ...
Published in: International journal of radiation oncology, biology, physics
November 2007

To review a historical cohort of consecutively accrued patients with high-risk neuroblastoma treated with intraoperative radiotherapy (IORT) to determine the therapeutic effect and late complications of this treatment.Between 1986 and 2002, 31 patients with newly diagnosed high-risk neuroblastoma were treated with IORT as part of multimodality therapy. Their medical records were reviewed to determine the outcome and complications. Kaplan-Meier probability estimates of local control, progression-free survival, and overall survival at 36 months after diagnosis were recorded.Intraoperative radiotherapy to the primary site and associated lymph nodes achieved excellent local control at a median follow-up of 44 months. The 3-year estimate of the local recurrence rate was 15%, less than that of most previously published series. Only 1 of 22 patients who had undergone gross total resection developed recurrence at the primary tumor site. The 3-year estimate of local control, progression-free survival, and overall survival was 85%, 47%, and 60%, respectively. Side effects attributable to either the disease process or multimodality treatment were observed in 7 patients who developed either hypertension or vascular stenosis. These late complications resulted in the death of 2 patients.Intraoperative radiotherapy at the time of primary resection offers effective local control in patients with high-risk neuroblastoma. Compared with historical controls, IORT achieved comparable control and survival rates while avoiding many side effects associated with external beam radiotherapy in young children. Although complications were observed, additional analysis is needed to determine the relative contributions of the disease process and specific components of the multimodality treatment to these adverse events.

Published In

International journal of radiation oncology, biology, physics

DOI

EISSN

1879-355X

ISSN

0360-3016

Publication Date

November 2007

Volume

69

Issue

3

Start / End Page

858 / 864

Related Subject Headings

  • Treatment Outcome
  • Prognosis
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Neoplasm Recurrence, Local
  • Intraoperative Period
  • Infant
  • Humans
  • Follow-Up Studies
  • Disease-Free Survival
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gillis, A. M., Sutton, E., Dewitt, K. D., Matthay, K. K., Weinberg, V., Fisch, B. M., … Haas-Kogan, D. (2007). Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma. International Journal of Radiation Oncology, Biology, Physics, 69(3), 858–864. https://doi.org/10.1016/j.ijrobp.2007.04.006
Gillis, Amy M., Elizabeth Sutton, Kelly D. Dewitt, Katherine K. Matthay, Vivian Weinberg, Benjamin M. Fisch, Albert Chan, et al. “Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma.International Journal of Radiation Oncology, Biology, Physics 69, no. 3 (November 2007): 858–64. https://doi.org/10.1016/j.ijrobp.2007.04.006.
Gillis AM, Sutton E, Dewitt KD, Matthay KK, Weinberg V, Fisch BM, et al. Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma. International journal of radiation oncology, biology, physics. 2007 Nov;69(3):858–64.
Gillis, Amy M., et al. “Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma.International Journal of Radiation Oncology, Biology, Physics, vol. 69, no. 3, Nov. 2007, pp. 858–64. Epmc, doi:10.1016/j.ijrobp.2007.04.006.
Gillis AM, Sutton E, Dewitt KD, Matthay KK, Weinberg V, Fisch BM, Chan A, Gooding C, Daldrup-Link H, Wara WM, Farmer DL, Harrison MR, Haas-Kogan D. Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma. International journal of radiation oncology, biology, physics. 2007 Nov;69(3):858–864.
Journal cover image

Published In

International journal of radiation oncology, biology, physics

DOI

EISSN

1879-355X

ISSN

0360-3016

Publication Date

November 2007

Volume

69

Issue

3

Start / End Page

858 / 864

Related Subject Headings

  • Treatment Outcome
  • Prognosis
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Neoplasm Recurrence, Local
  • Intraoperative Period
  • Infant
  • Humans
  • Follow-Up Studies
  • Disease-Free Survival