Skip to main content

Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension.

Publication ,  Journal Article
Rakow-Penner, RA; White, NS; Parsons, JK; Choi, HW; Liss, MA; Kuperman, JM; Schenker-Ahmed, N; Bartsch, H; Mattrey, RF; Bradley, WG; Shabaik, A ...
Published in: Prostate Cancer Prostatic Dis
March 2015

BACKGROUND: Standard magnetic resonance imaging (MRI) of the prostate lacks sensitivity in the diagnosis and staging of prostate cancer (PCa). To improve the operating characteristics of prostate MRI in the detection and characterization of PCa, we developed a novel, enhanced MRI diffusion technique using restriction spectrum imaging (RSI-MRI). METHODS: We compared the efficacy of our novel RSI-MRI technique with standard MRI for detecting extraprostatic extension (EPE) among 28 PCa patients who underwent MRI and RSI-MRI prior to radical prostatectomy, 10 with histologically proven pT3 disease. RSI cellularity maps isolating the restricted isotropic water fraction were reconstructed based on all b-values and then standardized across the sample with z-score maps. Distortion correction of the RSI maps was performed using the alternating phase-encode technique. RESULTS: 27 patients were evaluated, excluding one patient where distortion could not be performed. Preoperative standard MRI correctly identified extraprostatic the extension in two of the nine pT3 (22%) patients, whereas RSI-MRI identified EPE in eight of nine (89%) patients. RSI-MRI correctly identified pT2 disease in the remaining 18 patients. CONCLUSIONS: In this proof of principle study, we conclude that our novel RSI-MRI technology is feasible and shows promise for substantially improving PCa imaging. Further translational studies of prostate RSI-MRI in the diagnosis and staging of PCa are indicated.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

March 2015

Volume

18

Issue

1

Start / End Page

81 / 85

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Radiography
  • Prostatic Neoplasms
  • Prostatectomy
  • Prostate-Specific Antigen
  • Prostate
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rakow-Penner, R. A., White, N. S., Parsons, J. K., Choi, H. W., Liss, M. A., Kuperman, J. M., … Dale, A. M. (2015). Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension. Prostate Cancer Prostatic Dis, 18(1), 81–85. https://doi.org/10.1038/pcan.2014.50
Rakow-Penner, R. A., N. S. White, J. K. Parsons, H. W. Choi, M. A. Liss, J. M. Kuperman, N. Schenker-Ahmed, et al. “Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension.Prostate Cancer Prostatic Dis 18, no. 1 (March 2015): 81–85. https://doi.org/10.1038/pcan.2014.50.
Rakow-Penner RA, White NS, Parsons JK, Choi HW, Liss MA, Kuperman JM, et al. Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension. Prostate Cancer Prostatic Dis. 2015 Mar;18(1):81–5.
Rakow-Penner, R. A., et al. “Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension.Prostate Cancer Prostatic Dis, vol. 18, no. 1, Mar. 2015, pp. 81–85. Pubmed, doi:10.1038/pcan.2014.50.
Rakow-Penner RA, White NS, Parsons JK, Choi HW, Liss MA, Kuperman JM, Schenker-Ahmed N, Bartsch H, Mattrey RF, Bradley WG, Shabaik A, Huang J, Margolis DJA, Raman SS, Marks L, Kane CJ, Reiter RE, Karow DS, Dale AM. Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension. Prostate Cancer Prostatic Dis. 2015 Mar;18(1):81–85.

Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

March 2015

Volume

18

Issue

1

Start / End Page

81 / 85

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Radiography
  • Prostatic Neoplasms
  • Prostatectomy
  • Prostate-Specific Antigen
  • Prostate
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging