Substance P receptor mediated maintenance of chronic inflammation in EAE.
Publication
, Journal Article
Reinke, EK; Johnson, MJ; Ling, C; Karman, J; Lee, J; Weinstock, JV; Sandor, M; Fabry, Z
Published in: Journal of neuroimmunology
November 2006
Substance P (SP) is a modulatory, pro-inflammatory neuropeptide. We investigated the role of the SP receptor, neurokinin-1 (NK-1), in EAE. Our data show that in the chronic phase, mice lacking NK-1 have improved mobility and decreased numbers of LFA-1 high CD4+ T cells and MOG-specific, IFN-gamma producing CD4+ T cells. SR140333, an NK-1 antagonist, administered alone during the chronic phase of EAE was not sufficient to ameliorate symptoms. These results indicate that SP, through NK-1, contributes to maintenance of CNS inflammation, and combining NK-1 antagonists with conventional anti-inflammatory treatments may enhance the success of treatments for diseases like multiple sclerosis.
Duke Scholars
Published In
Journal of neuroimmunology
DOI
EISSN
1872-8421
ISSN
0165-5728
Publication Date
November 2006
Volume
180
Issue
1-2
Start / End Page
117 / 125
Related Subject Headings
- Substance P
- Receptors, Neurokinin-1
- Quinuclidines
- Piperidines
- Neurology & Neurosurgery
- Neurokinin-1 Receptor Antagonists
- Neuroimmunomodulation
- Myelin-Oligodendrocyte Glycoprotein
- Myelin-Associated Glycoprotein
- Myelin Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Reinke, E. K., Johnson, M. J., Ling, C., Karman, J., Lee, J., Weinstock, J. V., … Fabry, Z. (2006). Substance P receptor mediated maintenance of chronic inflammation in EAE. Journal of Neuroimmunology, 180(1–2), 117–125. https://doi.org/10.1016/j.jneuroim.2006.07.010
Reinke, Emily K., Matthew J. Johnson, Changying Ling, Jozsef Karman, Jangeun Lee, Joel V. Weinstock, Matyas Sandor, and Zsuzsa Fabry. “Substance P receptor mediated maintenance of chronic inflammation in EAE.” Journal of Neuroimmunology 180, no. 1–2 (November 2006): 117–25. https://doi.org/10.1016/j.jneuroim.2006.07.010.
Reinke EK, Johnson MJ, Ling C, Karman J, Lee J, Weinstock JV, et al. Substance P receptor mediated maintenance of chronic inflammation in EAE. Journal of neuroimmunology. 2006 Nov;180(1–2):117–25.
Reinke, Emily K., et al. “Substance P receptor mediated maintenance of chronic inflammation in EAE.” Journal of Neuroimmunology, vol. 180, no. 1–2, Nov. 2006, pp. 117–25. Epmc, doi:10.1016/j.jneuroim.2006.07.010.
Reinke EK, Johnson MJ, Ling C, Karman J, Lee J, Weinstock JV, Sandor M, Fabry Z. Substance P receptor mediated maintenance of chronic inflammation in EAE. Journal of neuroimmunology. 2006 Nov;180(1–2):117–125.
Published In
Journal of neuroimmunology
DOI
EISSN
1872-8421
ISSN
0165-5728
Publication Date
November 2006
Volume
180
Issue
1-2
Start / End Page
117 / 125
Related Subject Headings
- Substance P
- Receptors, Neurokinin-1
- Quinuclidines
- Piperidines
- Neurology & Neurosurgery
- Neurokinin-1 Receptor Antagonists
- Neuroimmunomodulation
- Myelin-Oligodendrocyte Glycoprotein
- Myelin-Associated Glycoprotein
- Myelin Proteins