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Histone modifications and chromatin organization in prostate cancer.

Publication ,  Journal Article
Chen, Z; Wang, L; Wang, Q; Li, W
Published in: Epigenomics
August 2010

Epigenetic mechanisms, including histone modifications, nucleosomal remodeling and chromosomal looping, contribute to the onset and progression of prostate cancer. Recent technical advances significantly increase our understanding of the genome-wide epigenetic regulation of gene expression in prostate cancer. Aberrant genomic distribution and global level of histone modifications, nucleosome repositioning at the gene promoter and enhancer regions, as well as androgen receptor-mediated chromosomal looping may lead to the silencing of tumor suppressor genes and the activation of proto-oncogenes. In addition, androgen receptor-induced chromosomal looping facilitates recurrent gene fusion in prostate cancer. Studies in epigenetic regulation have translational implications in the identification of new biomarkers and the development of new therapies in prostate cancer.

Duke Scholars

Published In

Epigenomics

DOI

EISSN

1750-192X

Publication Date

August 2010

Volume

2

Issue

4

Start / End Page

551 / 560

Location

England

Related Subject Headings

  • Prostatic Neoplasms
  • Male
  • Humans
  • Histones
  • High-Throughput Nucleotide Sequencing
  • Genes, Tumor Suppressor
  • Gene Silencing
  • Gene Expression Regulation, Neoplastic
  • Epigenesis, Genetic
  • Chromatin Immunoprecipitation
 

Citation

APA
Chicago
ICMJE
MLA
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Chen, Z., Wang, L., Wang, Q., & Li, W. (2010). Histone modifications and chromatin organization in prostate cancer. Epigenomics, 2(4), 551–560. https://doi.org/10.2217/epi.10.31
Chen, Zhong, Liguo Wang, Qianben Wang, and Wei Li. “Histone modifications and chromatin organization in prostate cancer.Epigenomics 2, no. 4 (August 2010): 551–60. https://doi.org/10.2217/epi.10.31.
Chen Z, Wang L, Wang Q, Li W. Histone modifications and chromatin organization in prostate cancer. Epigenomics. 2010 Aug;2(4):551–60.
Chen, Zhong, et al. “Histone modifications and chromatin organization in prostate cancer.Epigenomics, vol. 2, no. 4, Aug. 2010, pp. 551–60. Pubmed, doi:10.2217/epi.10.31.
Chen Z, Wang L, Wang Q, Li W. Histone modifications and chromatin organization in prostate cancer. Epigenomics. 2010 Aug;2(4):551–560.
Journal cover image

Published In

Epigenomics

DOI

EISSN

1750-192X

Publication Date

August 2010

Volume

2

Issue

4

Start / End Page

551 / 560

Location

England

Related Subject Headings

  • Prostatic Neoplasms
  • Male
  • Humans
  • Histones
  • High-Throughput Nucleotide Sequencing
  • Genes, Tumor Suppressor
  • Gene Silencing
  • Gene Expression Regulation, Neoplastic
  • Epigenesis, Genetic
  • Chromatin Immunoprecipitation