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Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.

Publication ,  Journal Article
Okeke, NL; Craig, DM; Muehlbauer, MJ; Ilkayeva, O; Clement, ME; Naggie, S; Shah, SH
Published in: Metabolomics
March 2018

INTRODUCTION: Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking. METHODS: Using tandem flow injection mass spectrometry, we quantified plasma levels of 60 metabolites in 24 matched pairs of PLWH [1:1 with and without known coronary artery disease (CAD)]. Metabolite levels were reduced to interpretable factors using principal components analysis. RESULTS: Factors derived from short-chain dicarboxylacylcarnitines (SCDA) (p = 0.08) and glutamine/valine (p = 0.003) were elevated in CAD cases compared to controls. CONCLUSION: SCDAs and glutamine/valine may be valuable markers of cardiovascular risk among persons living with HIV in the future, pending validation in larger cohorts.

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Published In

Metabolomics

DOI

EISSN

1573-3890

Publication Date

March 2018

Volume

14

Issue

3

Location

United States

Related Subject Headings

  • Valine
  • Middle Aged
  • Metabolome
  • Male
  • Humans
  • HIV Infections
  • Glutamine
  • Female
  • Carnitine
  • Cardiovascular Diseases
 

Citation

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Okeke, N. L., Craig, D. M., Muehlbauer, M. J., Ilkayeva, O., Clement, M. E., Naggie, S., & Shah, S. H. (2018). Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study. Metabolomics, 14(3). https://doi.org/10.1007/s11306-018-1318-z
Okeke, Nwora Lance, Damian M. Craig, Michael J. Muehlbauer, Olga Ilkayeva, Meredith E. Clement, Susanna Naggie, and Svati H. Shah. “Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.Metabolomics 14, no. 3 (March 2018). https://doi.org/10.1007/s11306-018-1318-z.
Okeke NL, Craig DM, Muehlbauer MJ, Ilkayeva O, Clement ME, Naggie S, et al. Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study. Metabolomics. 2018 Mar;14(3).
Okeke, Nwora Lance, et al. “Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.Metabolomics, vol. 14, no. 3, Mar. 2018. Pubmed, doi:10.1007/s11306-018-1318-z.
Okeke NL, Craig DM, Muehlbauer MJ, Ilkayeva O, Clement ME, Naggie S, Shah SH. Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study. Metabolomics. 2018 Mar;14(3).
Journal cover image

Published In

Metabolomics

DOI

EISSN

1573-3890

Publication Date

March 2018

Volume

14

Issue

3

Location

United States

Related Subject Headings

  • Valine
  • Middle Aged
  • Metabolome
  • Male
  • Humans
  • HIV Infections
  • Glutamine
  • Female
  • Carnitine
  • Cardiovascular Diseases