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Production and secretion of proteolytic enzymes by normal and neoplastic cells.

Publication ,  Journal Article
Boyd, JB; Farb, RM; Yost, FJ; Georgiade, N; Lazarus, GS
Published in: J Surg Oncol
1979

A possible mechanism for tumor cell invasion of normal tissue might be secretion of proteolytic enzymes. This study compares and contrasts production and secretion of proteinases by cell cultures of normal and chemically transformed mouse epithelial cells. Lysates of normal and neoplastic cells contain similar amounts of neutral proteinase, cathepsin D and plasminogen activator. Neither collagenase nor elastase could be identified in lysates of, or serum-free culture medium bathing, normal or neoplastic cells. Neoplastic cells secrete ten times more plasminogen activator than normal cells. Our data support the hypothesis that plasminogen activator produced by neoplastic cells could fuction to activate latent proteolytic enzymes secreted by connective tissue cells which might result in spread of neoplastic cells into normal tissue.

Duke Scholars

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

1979

Volume

11

Issue

3

Start / End Page

275 / 282

Location

United States

Related Subject Headings

  • Plasminogen Activators
  • Peptide Hydrolases
  • Oncology & Carcinogenesis
  • Mice
  • Epithelium
  • Cells, Cultured
  • Cell Transformation, Neoplastic
  • Cathepsins
  • Animals
  • 3211 Oncology and carcinogenesis
 

Citation

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Boyd, J. B., Farb, R. M., Yost, F. J., Georgiade, N., & Lazarus, G. S. (1979). Production and secretion of proteolytic enzymes by normal and neoplastic cells. J Surg Oncol, 11(3), 275–282. https://doi.org/10.1002/jso.2930110314
Boyd, J. B., R. M. Farb, F. J. Yost, N. Georgiade, and G. S. Lazarus. “Production and secretion of proteolytic enzymes by normal and neoplastic cells.J Surg Oncol 11, no. 3 (1979): 275–82. https://doi.org/10.1002/jso.2930110314.
Boyd JB, Farb RM, Yost FJ, Georgiade N, Lazarus GS. Production and secretion of proteolytic enzymes by normal and neoplastic cells. J Surg Oncol. 1979;11(3):275–82.
Boyd, J. B., et al. “Production and secretion of proteolytic enzymes by normal and neoplastic cells.J Surg Oncol, vol. 11, no. 3, 1979, pp. 275–82. Pubmed, doi:10.1002/jso.2930110314.
Boyd JB, Farb RM, Yost FJ, Georgiade N, Lazarus GS. Production and secretion of proteolytic enzymes by normal and neoplastic cells. J Surg Oncol. 1979;11(3):275–282.
Journal cover image

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

1979

Volume

11

Issue

3

Start / End Page

275 / 282

Location

United States

Related Subject Headings

  • Plasminogen Activators
  • Peptide Hydrolases
  • Oncology & Carcinogenesis
  • Mice
  • Epithelium
  • Cells, Cultured
  • Cell Transformation, Neoplastic
  • Cathepsins
  • Animals
  • 3211 Oncology and carcinogenesis