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The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma.

Publication ,  Journal Article
Morrissey, JJ; Kharasch, ED
Published in: J Urol
May 2013

PURPOSE: Renal cancer is frequently asymptomatic until late stages of the disease and it has a poor prognosis when not discovered early. AQP1 and PLIN2 are recently discovered, sensitive urine biomarkers of clear cell and papillary kidney cancer. We validated these biomarkers in a second cohort of patients and determined the effect of common kidney diseases on specificity. MATERIALS AND METHODS: Urine samples were obtained from 36 patients with clear cell or papillary kidney cancer, 43 controls, 44 patients with documented urinary tract infection, 24 diagnosed with diabetic nephropathy and 18 diagnosed with glomerulonephritis. Urine levels of AQP1 and PLIN2 normalized to urine creatinine were determined by a sensitive, specific Western blot procedure. RESULTS: Compared with controls, urine AQP1 and PLIN2 levels in patients with kidney cancer were 23-fold and fourfold greater, respectively, and they decreased 83% to 84% after tumor excision. There was a linear correlation between urine AQP1 and PLIN2 levels, and tumor size (each p <0.001). Urine AQP1 and PLIN2 levels in patients with kidney cancer were 11 to 23-fold and 17 to 25-fold greater, respectively, than in patients with the common kidney diseases. CONCLUSIONS: The ability of urine AQP1 and PLIN2 to identify patients with kidney cancer compared to controls was validated in a second cohort of patients. Common kidney diseases do not adversely increase urine AQP1 and PLIN2 levels or decrease their specificity to screen for renal cancer.

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Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

May 2013

Volume

189

Issue

5

Start / End Page

1913 / 1920

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Sensitivity and Specificity
  • Perilipin-2
  • Membrane Proteins
  • Male
  • Kidney Neoplasms
  • Humans
  • Female
  • Early Detection of Cancer
  • Carcinoma, Renal Cell
 

Citation

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Morrissey, J. J., & Kharasch, E. D. (2013). The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma. J Urol, 189(5), 1913–1920. https://doi.org/10.1016/j.juro.2012.11.034
Morrissey, Jeremiah J., and Evan D. Kharasch. “The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma.J Urol 189, no. 5 (May 2013): 1913–20. https://doi.org/10.1016/j.juro.2012.11.034.
Morrissey JJ, Kharasch ED. The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma. J Urol. 2013 May;189(5):1913–20.
Morrissey, Jeremiah J., and Evan D. Kharasch. “The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma.J Urol, vol. 189, no. 5, May 2013, pp. 1913–20. Pubmed, doi:10.1016/j.juro.2012.11.034.
Morrissey JJ, Kharasch ED. The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma. J Urol. 2013 May;189(5):1913–1920.
Journal cover image

Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

May 2013

Volume

189

Issue

5

Start / End Page

1913 / 1920

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Sensitivity and Specificity
  • Perilipin-2
  • Membrane Proteins
  • Male
  • Kidney Neoplasms
  • Humans
  • Female
  • Early Detection of Cancer
  • Carcinoma, Renal Cell