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Automated radiosynthesis of [11C]morphine for clinical investigation.

Publication ,  Journal Article
Fan, J; Meissner, K; Gaehle, GG; Li, S; Kharasch, ED; Mach, RH; Tu, Z
Published in: Appl Radiat Isot
February 2011

To meet a multiple-dose clinical evaluation of the P-gp modulation of [(11)C]morphine delivery into the human brain, radiosynthesis of [(11)C]morphine was accomplished on an automated system by N-methylation of normorphine with [(11)C]CH(3)I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45 min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26 Ci/μmol (decay corrected to end-of-bombardment); radiochemical and chemical purities were >95% (n=28).

Duke Scholars

Published In

Appl Radiat Isot

DOI

EISSN

1872-9800

Publication Date

February 2011

Volume

69

Issue

2

Start / End Page

431 / 435

Location

England

Related Subject Headings

  • Solid Phase Extraction
  • Radiopharmaceuticals
  • Nuclear Medicine & Medical Imaging
  • Morphine
  • Methylation
  • Isotope Labeling
  • Carbon Radioisotopes
  • Automation, Laboratory
  • 1103 Clinical Sciences
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fan, J., Meissner, K., Gaehle, G. G., Li, S., Kharasch, E. D., Mach, R. H., & Tu, Z. (2011). Automated radiosynthesis of [11C]morphine for clinical investigation. Appl Radiat Isot, 69(2), 431–435. https://doi.org/10.1016/j.apradiso.2010.11.003
Fan, Jinda, Konrad Meissner, Gregory G. Gaehle, Shihong Li, Evan D. Kharasch, Robert H. Mach, and Zhude Tu. “Automated radiosynthesis of [11C]morphine for clinical investigation.Appl Radiat Isot 69, no. 2 (February 2011): 431–35. https://doi.org/10.1016/j.apradiso.2010.11.003.
Fan J, Meissner K, Gaehle GG, Li S, Kharasch ED, Mach RH, et al. Automated radiosynthesis of [11C]morphine for clinical investigation. Appl Radiat Isot. 2011 Feb;69(2):431–5.
Fan, Jinda, et al. “Automated radiosynthesis of [11C]morphine for clinical investigation.Appl Radiat Isot, vol. 69, no. 2, Feb. 2011, pp. 431–35. Pubmed, doi:10.1016/j.apradiso.2010.11.003.
Fan J, Meissner K, Gaehle GG, Li S, Kharasch ED, Mach RH, Tu Z. Automated radiosynthesis of [11C]morphine for clinical investigation. Appl Radiat Isot. 2011 Feb;69(2):431–435.
Journal cover image

Published In

Appl Radiat Isot

DOI

EISSN

1872-9800

Publication Date

February 2011

Volume

69

Issue

2

Start / End Page

431 / 435

Location

England

Related Subject Headings

  • Solid Phase Extraction
  • Radiopharmaceuticals
  • Nuclear Medicine & Medical Imaging
  • Morphine
  • Methylation
  • Isotope Labeling
  • Carbon Radioisotopes
  • Automation, Laboratory
  • 1103 Clinical Sciences
  • 0299 Other Physical Sciences