Automated radiosynthesis of [11C]morphine for clinical investigation.
Publication
, Journal Article
Fan, J; Meissner, K; Gaehle, GG; Li, S; Kharasch, ED; Mach, RH; Tu, Z
Published in: Appl Radiat Isot
February 2011
To meet a multiple-dose clinical evaluation of the P-gp modulation of [(11)C]morphine delivery into the human brain, radiosynthesis of [(11)C]morphine was accomplished on an automated system by N-methylation of normorphine with [(11)C]CH(3)I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45 min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26 Ci/μmol (decay corrected to end-of-bombardment); radiochemical and chemical purities were >95% (n=28).
Duke Scholars
Published In
Appl Radiat Isot
DOI
EISSN
1872-9800
Publication Date
February 2011
Volume
69
Issue
2
Start / End Page
431 / 435
Location
England
Related Subject Headings
- Solid Phase Extraction
- Radiopharmaceuticals
- Nuclear Medicine & Medical Imaging
- Morphine
- Methylation
- Isotope Labeling
- Carbon Radioisotopes
- Automation, Laboratory
- 1103 Clinical Sciences
- 0299 Other Physical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Fan, J., Meissner, K., Gaehle, G. G., Li, S., Kharasch, E. D., Mach, R. H., & Tu, Z. (2011). Automated radiosynthesis of [11C]morphine for clinical investigation. Appl Radiat Isot, 69(2), 431–435. https://doi.org/10.1016/j.apradiso.2010.11.003
Fan, Jinda, Konrad Meissner, Gregory G. Gaehle, Shihong Li, Evan D. Kharasch, Robert H. Mach, and Zhude Tu. “Automated radiosynthesis of [11C]morphine for clinical investigation.” Appl Radiat Isot 69, no. 2 (February 2011): 431–35. https://doi.org/10.1016/j.apradiso.2010.11.003.
Fan J, Meissner K, Gaehle GG, Li S, Kharasch ED, Mach RH, et al. Automated radiosynthesis of [11C]morphine for clinical investigation. Appl Radiat Isot. 2011 Feb;69(2):431–5.
Fan, Jinda, et al. “Automated radiosynthesis of [11C]morphine for clinical investigation.” Appl Radiat Isot, vol. 69, no. 2, Feb. 2011, pp. 431–35. Pubmed, doi:10.1016/j.apradiso.2010.11.003.
Fan J, Meissner K, Gaehle GG, Li S, Kharasch ED, Mach RH, Tu Z. Automated radiosynthesis of [11C]morphine for clinical investigation. Appl Radiat Isot. 2011 Feb;69(2):431–435.
Published In
Appl Radiat Isot
DOI
EISSN
1872-9800
Publication Date
February 2011
Volume
69
Issue
2
Start / End Page
431 / 435
Location
England
Related Subject Headings
- Solid Phase Extraction
- Radiopharmaceuticals
- Nuclear Medicine & Medical Imaging
- Morphine
- Methylation
- Isotope Labeling
- Carbon Radioisotopes
- Automation, Laboratory
- 1103 Clinical Sciences
- 0299 Other Physical Sciences