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Rationale and design of the Statins Evaluation in Coronary procedUres and REvascularization: The SECURE-PCI Trial.

Publication ,  Journal Article
Berwanger, O; de Barros E Silva, PGM; Dall Orto, FTC; de Andrade, PB; de Castro Bienert, IR; Bosso, CE; Mangione, J; Polanczyk, CA; Sousa, A ...
Published in: Am Heart J
April 2018

BACKGROUND: Previous evidence suggests that acute treatment with statins reduce atherosclerotic complications, including periprocedural myocardial infarction, but currently, there are no large, adequately powered studies to define the effects of early, high-dose statins in patients with acute coronary syndrome (ACS) and planned invasive management. OBJECTIVES: The main goal of Statins Evaluation in Coronary procedUres and REvascularization (SECURE-PCI) Trial is to determine whether the early use of a loading dose of 80 mg of atorvastatin before an intended percutaneous coronary intervention followed by an additional dose of 80 mg 24 hours after the procedure will be able to reduce the rates of major cardiovascular events at 30 days in patients with an ACS. DESIGN: The SECURE-PCI study is a pragmatic, multicenter, double-blind, placebo-controlled randomized trial planned to enroll around 4,200 patients in 58 different sites in Brazil. The primary outcome is the rate of major cardiovascular events at 30 days defined as a composite of all-cause mortality, nonfatal acute myocardial infarction, nonfatal stroke, and coronary revascularization. SUMMARY: The SECURE PCI is a large randomized trial testing a strategy of early, high-dose statin in patients with ACS and will provide important information about the acute treatment of this patient population.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

April 2018

Volume

198

Start / End Page

129 / 134

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Risk Assessment
  • Proportional Hazards Models
  • Prognosis
  • Preoperative Care
  • Postoperative Care
  • Percutaneous Coronary Intervention
  • Myocardial Revascularization
  • Middle Aged
 

Citation

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Berwanger, O., de Barros E Silva, P. G. M., Dall Orto, F. T. C., de Andrade, P. B., de Castro Bienert, I. R., Bosso, C. E., … Lopes, R. D. (2018). Rationale and design of the Statins Evaluation in Coronary procedUres and REvascularization: The SECURE-PCI Trial. Am Heart J, 198, 129–134. https://doi.org/10.1016/j.ahj.2017.12.018
Berwanger, Otavio, Pedro G. M. de Barros E Silva, Frederico Toledo Campo Dall Orto, Pedro Beraldo de Andrade, Igor Ribeiro de Castro Bienert, Carlos Eduardo Bosso, José Mangione, et al. “Rationale and design of the Statins Evaluation in Coronary procedUres and REvascularization: The SECURE-PCI Trial.Am Heart J 198 (April 2018): 129–34. https://doi.org/10.1016/j.ahj.2017.12.018.
Berwanger O, de Barros E Silva PGM, Dall Orto FTC, de Andrade PB, de Castro Bienert IR, Bosso CE, et al. Rationale and design of the Statins Evaluation in Coronary procedUres and REvascularization: The SECURE-PCI Trial. Am Heart J. 2018 Apr;198:129–34.
Berwanger, Otavio, et al. “Rationale and design of the Statins Evaluation in Coronary procedUres and REvascularization: The SECURE-PCI Trial.Am Heart J, vol. 198, Apr. 2018, pp. 129–34. Pubmed, doi:10.1016/j.ahj.2017.12.018.
Berwanger O, de Barros E Silva PGM, Dall Orto FTC, de Andrade PB, de Castro Bienert IR, Bosso CE, Mangione J, Polanczyk CA, Sousa A, Kalil R, de Moura Santos L, Sposito AC, Rech RL, Sousa ACS, Baldissera F, Nascimento BR, de Andrade Jesuíno I, Santucci EV, Damiani LP, Laranjeira LN, Borges de Oliveira JA, Giraldez RR, Cavalcanti AB, Pereira SB, Mattos LA, Armaganijan LV, Guimarães HP, Sousa JE, Alexander JH, Granger CB, Lopes RD. Rationale and design of the Statins Evaluation in Coronary procedUres and REvascularization: The SECURE-PCI Trial. Am Heart J. 2018 Apr;198:129–134.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

April 2018

Volume

198

Start / End Page

129 / 134

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Risk Assessment
  • Proportional Hazards Models
  • Prognosis
  • Preoperative Care
  • Postoperative Care
  • Percutaneous Coronary Intervention
  • Myocardial Revascularization
  • Middle Aged