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Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study.

Publication ,  Journal Article
Butler, J; Kalogeropoulos, AP; Anstrom, KJ; Hsue, PY; Kim, RJ; Scherzer, R; Shah, SJ; Shah, SH; Velazquez, EJ; Hernandez, AF; Braunwald, E ...
Published in: J Card Fail
April 2018

Antiretroviral therapy (ART) has been associated with a shift in the epidemiology of human immunodeficiency virus (HIV)-associated cardiomyopathy from a phenotype of primarily left ventricular (LV) systolic dysfunction to LV diastolic dysfunction (DD). Patients with HIV receiving ART have higher rates of DD compared with age-matched control subjects and develop DD at a younger age. However, little is known about the natural history and pathogenesis of DD in virally suppressed HIV-infected patients. Current evidence suggests that immune processes modulate the risk for cardiac involvement in HIV-infected persons. Ongoing inflammation appears to have myocardial effects, and accelerated myocardial fibrosis appears to be a key mediator of HIV-induced DD. The Characterizing Heart Function on Antiretroviral Therapy (CHART) study aims to systematically investigate determinants, mechanisms, and consequences of DD in HIV-infected patients. We will compare ART-treated virally suppressed HIV-infected individuals with and without DD and HIV- individuals with DD regarding (1) systemic inflammation, myocardial stress, and subclinical myocardial necrosis as indicated by circulating biomarkers; (2) immune system activation as indicated by cell surface receptors; (3) myocardial fibrosis according to cardiac magnetic resonance examination; (4) markers of fibrosis and remodeling, oxidative stress, and hypercoagulability; (5) left atrial function according to echocardiographic examination; (6) myocardial stress and subclinical necrosis as indicated by circulating biomarkers; (7) proteomic and metabolic profiles; and (8) phenotype signatures derived from clinical, biomarker, and imaging data.

Duke Scholars

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

April 2018

Volume

24

Issue

4

Start / End Page

255 / 265

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Prognosis
  • Incidence
  • Humans
  • Heart Failure, Diastolic
  • HIV Infections
  • HIV
  • Global Health
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
MLA
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Butler, J., Kalogeropoulos, A. P., Anstrom, K. J., Hsue, P. Y., Kim, R. J., Scherzer, R., … Braunwald, E. (2018). Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study. J Card Fail, 24(4), 255–265. https://doi.org/10.1016/j.cardfail.2018.02.001
Butler, Javed, Andreas P. Kalogeropoulos, Kevin J. Anstrom, Priscilla Y. Hsue, Raymond J. Kim, Rebecca Scherzer, Sanjiv J. Shah, et al. “Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study.J Card Fail 24, no. 4 (April 2018): 255–65. https://doi.org/10.1016/j.cardfail.2018.02.001.
Butler J, Kalogeropoulos AP, Anstrom KJ, Hsue PY, Kim RJ, Scherzer R, Shah SJ, Shah SH, Velazquez EJ, Hernandez AF, Desvigne-Nickens P, Braunwald E. Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study. J Card Fail. 2018 Apr;24(4):255–265.
Journal cover image

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

April 2018

Volume

24

Issue

4

Start / End Page

255 / 265

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Prognosis
  • Incidence
  • Humans
  • Heart Failure, Diastolic
  • HIV Infections
  • HIV
  • Global Health
  • Cardiovascular System & Hematology