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Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.

Publication ,  Journal Article
Ji, R-R; Nackley, A; Huh, Y; Terrando, N; Maixner, W
Published in: Anesthesiology
August 2018

Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness in central pain pathways after painful insults. Accumulating evidence suggests that central sensitization is also driven by neuroinflammation in the peripheral and central nervous system. A characteristic feature of neuroinflammation is the activation of glial cells, such as microglia and astrocytes, in the spinal cord and brain, leading to the release of proinflammatory cytokines and chemokines. Recent studies suggest that central cytokines and chemokines are powerful neuromodulators and play a sufficient role in inducing hyperalgesia and allodynia after central nervous system administration. Sustained increase of cytokines and chemokines in the central nervous system also promotes chronic widespread pain that affects multiple body sites. Thus, neuroinflammation drives widespread chronic pain via central sensitization. We also discuss sex-dependent glial/immune signaling in chronic pain and new therapeutic approaches that control neuroinflammation for the resolution of chronic pain.

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Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

August 2018

Volume

129

Issue

2

Start / End Page

343 / 366

Location

United States

Related Subject Headings

  • Pain Management
  • Inflammation Mediators
  • Inflammation
  • Humans
  • Gliosis
  • Clinical Trials as Topic
  • Chronic Pain
  • Central Nervous System Sensitization
  • Animals
  • Anesthesiology
 

Citation

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Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018). Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. Anesthesiology, 129(2), 343–366. https://doi.org/10.1097/ALN.0000000000002130
Ji, Ru-Rong, Andrea Nackley, Yul Huh, Niccolò Terrando, and William Maixner. “Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.Anesthesiology 129, no. 2 (August 2018): 343–66. https://doi.org/10.1097/ALN.0000000000002130.
Ji R-R, Nackley A, Huh Y, Terrando N, Maixner W. Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. Anesthesiology. 2018 Aug;129(2):343–66.
Ji, Ru-Rong, et al. “Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.Anesthesiology, vol. 129, no. 2, Aug. 2018, pp. 343–66. Pubmed, doi:10.1097/ALN.0000000000002130.
Ji R-R, Nackley A, Huh Y, Terrando N, Maixner W. Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. Anesthesiology. 2018 Aug;129(2):343–366.

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

August 2018

Volume

129

Issue

2

Start / End Page

343 / 366

Location

United States

Related Subject Headings

  • Pain Management
  • Inflammation Mediators
  • Inflammation
  • Humans
  • Gliosis
  • Clinical Trials as Topic
  • Chronic Pain
  • Central Nervous System Sensitization
  • Animals
  • Anesthesiology