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Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress.

Publication ,  Journal Article
Trub, AG; Hirschey, MD
Published in: Trends Biochem Sci
May 2018

In recent years, our understanding of the scope and diversity of protein post-translational modifications (PTMs) has rapidly expanded. In particular, mitochondrial proteins are decorated with an array of acyl groups that can occur non-enzymatically. Interestingly, these modifying chemical moieties are often associated with intermediary metabolites from core metabolic pathways. In this Review, we describe biochemical reactions and biological mechanisms that activate carbon metabolites for protein PTM. We explore the emerging links between the intrinsic reactivity of metabolites, non-enzymatic protein acylation, and possible signaling roles for this system. Finally, we propose a model of 'carbon stress', similar to oxidative stress, as an effective way to conceptualize the relationship between widespread protein acylation, nutrient sensing, and metabolic homeostasis.

Duke Scholars

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Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

May 2018

Volume

43

Issue

5

Start / End Page

369 / 379

Location

England

Related Subject Headings

  • Substrate Specificity
  • Protein Processing, Post-Translational
  • Oxidative Stress
  • Humans
  • Developmental Biology
  • Carbon
  • Animals
  • Acyl Coenzyme A
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics
 

Citation

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Trub, A. G., & Hirschey, M. D. (2018). Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress. Trends Biochem Sci, 43(5), 369–379. https://doi.org/10.1016/j.tibs.2018.02.002
Trub, Alec G., and Matthew D. Hirschey. “Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress.Trends Biochem Sci 43, no. 5 (May 2018): 369–79. https://doi.org/10.1016/j.tibs.2018.02.002.
Trub AG, Hirschey MD. Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress. Trends Biochem Sci. 2018 May;43(5):369–79.
Trub, Alec G., and Matthew D. Hirschey. “Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress.Trends Biochem Sci, vol. 43, no. 5, May 2018, pp. 369–79. Pubmed, doi:10.1016/j.tibs.2018.02.002.
Trub AG, Hirschey MD. Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress. Trends Biochem Sci. 2018 May;43(5):369–379.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

May 2018

Volume

43

Issue

5

Start / End Page

369 / 379

Location

England

Related Subject Headings

  • Substrate Specificity
  • Protein Processing, Post-Translational
  • Oxidative Stress
  • Humans
  • Developmental Biology
  • Carbon
  • Animals
  • Acyl Coenzyme A
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics