Encyclopedia of Biological Chemistry: Second Edition
Recombination-Dependent DNA Replication
Publication
, Chapter
Kreuzer, KN
February 15, 2013
For many years, homologous genetic recombination and DNA replication were studied in isolation from one another. However, beginning with studies of bacteriophages in the 1960s and 1970s, the possibility emerged that extensive DNA replication can sometimes be triggered by homologous recombination. More recently, scientists working with diverse organisms have shown that recombination-dependent DNA replication (RDR) is common and that this process provides an important back-up mechanism for completing DNA replication when replication forks fail. Mutational inactivation of certain proteins that are involved in RDR or related processes can lead to genome instability and a predisposition to cancer in higher organisms.
Duke Scholars
DOI
ISBN
9780123786302
Publication Date
February 15, 2013
Start / End Page
23 / 28
Citation
APA
Chicago
ICMJE
MLA
NLM
Kreuzer, K. N. (2013). Recombination-Dependent DNA Replication. In Encyclopedia of Biological Chemistry: Second Edition (pp. 23–28). https://doi.org/10.1016/B978-0-12-378630-2.00257-7
Kreuzer, K. N. “Recombination-Dependent DNA Replication.” In Encyclopedia of Biological Chemistry: Second Edition, 23–28, 2013. https://doi.org/10.1016/B978-0-12-378630-2.00257-7.
Kreuzer KN. Recombination-Dependent DNA Replication. In: Encyclopedia of Biological Chemistry: Second Edition. 2013. p. 23–8.
Kreuzer, K. N. “Recombination-Dependent DNA Replication.” Encyclopedia of Biological Chemistry: Second Edition, 2013, pp. 23–28. Scopus, doi:10.1016/B978-0-12-378630-2.00257-7.
Kreuzer KN. Recombination-Dependent DNA Replication. Encyclopedia of Biological Chemistry: Second Edition. 2013. p. 23–28.
DOI
ISBN
9780123786302
Publication Date
February 15, 2013
Start / End Page
23 / 28