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Caregiver-Reported Sleep Disturbances Are Associated With Behavioral and Psychological Symptoms in an Asian Elderly Cohort With Cognitive Impairment-No Dementia.

Publication ,  Journal Article
Xu, X; Kan, CN; Wong, TY; Cheng, C-Y; Ikram, MK; Chen, CL-H; Venketasubramanian, N
Published in: J Geriatr Psychiatry Neurol
March 2018

OBJECTIVE: Sleep disturbances were found to be associated with more behavioral and psychological symptoms (BPS) in early patients with Alzheimer's disease (AD). However, data on preclinical stages of dementia are lacking. Hence, the present study sought to investigate the association between sleep disturbances and BPS in dementia-free elderly with varying severity of cognitive impairment in an Asian sample. METHODS: Community-living elderly were recruited and administered a comprehensive cognitive battery (vascular dementia battery [VDB]) and the Neuropsychiatric Inventory to assess symptoms of sleep disturbances and BPS. Severity of cognitive impairment was diagnosed and classified as no cognitive impairment (NCI), cognitive impairment-no dementia (CIND) -mild (1-2 impaired domains on the VDB), and CIND-moderate (≥3 impaired domains on the VDB). Analysis of variance was conducted to assess the associations between the presence of sleep disturbances and BPS scores in each diagnostic group. Logistic regression was used to examine whether the coexistence of sleep disturbances and other BPS was associated with CIND-moderate, which is known to carry a higher risk of progression to AD. RESULTS: Among 839 elderly, 79 (9.4%) reported sleep disturbances. Participants with sleep disturbances had higher total BPS burden than those without among CIND participants but not in NCIs. Furthermore, CIND-moderate participants with sleep disturbances had more delusions, hallucinations, anxiety, depression, irritability, aberrant motor behavior, and appetite change ( P < .05). The presence of both sleep disturbances and other BPS was associated with CIND-moderate (odds ratio: 2.5, 95% confidence interval: 1.1-5.5). CONCLUSIONS: Sleep disturbances are associated with higher total BPS burden and specific BPS among elderly patients with cognitive impairment, particularly those with CIND moderate, which carries higher risk of developing dementia.

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Published In

J Geriatr Psychiatry Neurol

DOI

ISSN

0891-9887

Publication Date

March 2018

Volume

31

Issue

2

Start / End Page

70 / 75

Location

United States

Related Subject Headings

  • Sleep Wake Disorders
  • Singapore
  • Mental Disorders
  • Male
  • Independent Living
  • Humans
  • Geriatrics
  • Female
  • Disease Progression
  • Depression
 

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Xu, X., Kan, C. N., Wong, T. Y., Cheng, C.-Y., Ikram, M. K., Chen, C.-H., & Venketasubramanian, N. (2018). Caregiver-Reported Sleep Disturbances Are Associated With Behavioral and Psychological Symptoms in an Asian Elderly Cohort With Cognitive Impairment-No Dementia. J Geriatr Psychiatry Neurol, 31(2), 70–75. https://doi.org/10.1177/0891988718758203
Xu, Xin, Cheuk Ni Kan, Tien Yin Wong, Ching-Yu Cheng, M Kamran Ikram, Christopher Li-Hsian Chen, and Narayanaswamy Venketasubramanian. “Caregiver-Reported Sleep Disturbances Are Associated With Behavioral and Psychological Symptoms in an Asian Elderly Cohort With Cognitive Impairment-No Dementia.J Geriatr Psychiatry Neurol 31, no. 2 (March 2018): 70–75. https://doi.org/10.1177/0891988718758203.
Xu X, Kan CN, Wong TY, Cheng C-Y, Ikram MK, Chen CL-H, et al. Caregiver-Reported Sleep Disturbances Are Associated With Behavioral and Psychological Symptoms in an Asian Elderly Cohort With Cognitive Impairment-No Dementia. J Geriatr Psychiatry Neurol. 2018 Mar;31(2):70–5.
Xu, Xin, et al. “Caregiver-Reported Sleep Disturbances Are Associated With Behavioral and Psychological Symptoms in an Asian Elderly Cohort With Cognitive Impairment-No Dementia.J Geriatr Psychiatry Neurol, vol. 31, no. 2, Mar. 2018, pp. 70–75. Pubmed, doi:10.1177/0891988718758203.
Xu X, Kan CN, Wong TY, Cheng C-Y, Ikram MK, Chen CL-H, Venketasubramanian N. Caregiver-Reported Sleep Disturbances Are Associated With Behavioral and Psychological Symptoms in an Asian Elderly Cohort With Cognitive Impairment-No Dementia. J Geriatr Psychiatry Neurol. 2018 Mar;31(2):70–75.
Journal cover image

Published In

J Geriatr Psychiatry Neurol

DOI

ISSN

0891-9887

Publication Date

March 2018

Volume

31

Issue

2

Start / End Page

70 / 75

Location

United States

Related Subject Headings

  • Sleep Wake Disorders
  • Singapore
  • Mental Disorders
  • Male
  • Independent Living
  • Humans
  • Geriatrics
  • Female
  • Disease Progression
  • Depression