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Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging.

Publication ,  Journal Article
Redman, LM; Smith, SR; Burton, JH; Martin, CK; Il'yasova, D; Ravussin, E
Published in: Cell Metab
April 3, 2018

Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we tested the hypothesis that energy expenditure (EE) and its endocrine mediators are reduced with a CR diet over 2 years. Approximately 15% CR was achieved over 2 years, resulting in an average 8.7 kg weight loss, whereas controls gained 1.8 kg. In the CR group, EE measured over 24 hr or during sleep was approximately 80-120 kcal/day lower than expected on the basis of weight loss, indicating sustained metabolic adaptation over 2 years. This metabolic adaptation was accompanied by significantly reduced thyroid axis activity and reactive oxygen species (F2-isoprostane) production. Findings from this 2-year CR trial in healthy, non-obese humans provide new evidence of persistent metabolic slowing accompanied by reduced oxidative stress, which supports the rate of living and oxidative damage theories of mammalian aging.

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Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

April 3, 2018

Volume

27

Issue

4

Start / End Page

805 / 815.e4

Location

United States

Related Subject Headings

  • Weight Loss
  • Oxidative Stress
  • Oxidation-Reduction
  • Middle Aged
  • Male
  • Humans
  • Female
  • Energy Metabolism
  • Endocrinology & Metabolism
  • Caloric Restriction
 

Citation

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Redman, L. M., Smith, S. R., Burton, J. H., Martin, C. K., Il’yasova, D., & Ravussin, E. (2018). Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. Cell Metab, 27(4), 805-815.e4. https://doi.org/10.1016/j.cmet.2018.02.019
Redman, Leanne M., Steven R. Smith, Jeffrey H. Burton, Corby K. Martin, Dora Il’yasova, and Eric Ravussin. “Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging.Cell Metab 27, no. 4 (April 3, 2018): 805-815.e4. https://doi.org/10.1016/j.cmet.2018.02.019.
Redman LM, Smith SR, Burton JH, Martin CK, Il’yasova D, Ravussin E. Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. Cell Metab. 2018 Apr 3;27(4):805-815.e4.
Redman, Leanne M., et al. “Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging.Cell Metab, vol. 27, no. 4, Apr. 2018, pp. 805-815.e4. Pubmed, doi:10.1016/j.cmet.2018.02.019.
Redman LM, Smith SR, Burton JH, Martin CK, Il’yasova D, Ravussin E. Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. Cell Metab. 2018 Apr 3;27(4):805-815.e4.
Journal cover image

Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

April 3, 2018

Volume

27

Issue

4

Start / End Page

805 / 815.e4

Location

United States

Related Subject Headings

  • Weight Loss
  • Oxidative Stress
  • Oxidation-Reduction
  • Middle Aged
  • Male
  • Humans
  • Female
  • Energy Metabolism
  • Endocrinology & Metabolism
  • Caloric Restriction