From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world.
Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma.
Duke Scholars
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Related Subject Headings
- Treatment Outcome
- Tomography, X-Ray Computed
- Tobacco Smoking
- Risk Factors
- Prevalence
- Practice Guidelines as Topic
- Non-alcoholic Fatty Liver Disease
- Neoplasm Staging
- Liver Transplantation
- Liver Neoplasms
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Treatment Outcome
- Tomography, X-Ray Computed
- Tobacco Smoking
- Risk Factors
- Prevalence
- Practice Guidelines as Topic
- Non-alcoholic Fatty Liver Disease
- Neoplasm Staging
- Liver Transplantation
- Liver Neoplasms