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From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world.

Publication ,  Journal Article
Dimitroulis, D; Damaskos, C; Valsami, S; Davakis, S; Garmpis, N; Spartalis, E; Athanasiou, A; Moris, D; Sakellariou, S; Kykalos, S; Garmpi, A ...
Published in: World journal of gastroenterology
August 2017

Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma.

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Published In

World journal of gastroenterology

DOI

EISSN

2219-2840

ISSN

1007-9327

Publication Date

August 2017

Volume

23

Issue

29

Start / End Page

5282 / 5294

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Tobacco Smoking
  • Risk Factors
  • Prevalence
  • Practice Guidelines as Topic
  • Non-alcoholic Fatty Liver Disease
  • Neoplasm Staging
  • Liver Transplantation
  • Liver Neoplasms
 

Citation

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Dimitroulis, D., Damaskos, C., Valsami, S., Davakis, S., Garmpis, N., Spartalis, E., … Kouraklis, G. (2017). From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world. World Journal of Gastroenterology, 23(29), 5282–5294. https://doi.org/10.3748/wjg.v23.i29.5282
Dimitroulis, Dimitrios, Christos Damaskos, Serena Valsami, Spyridon Davakis, Nikolaos Garmpis, Eleftherios Spartalis, Antonios Athanasiou, et al. “From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world.World Journal of Gastroenterology 23, no. 29 (August 2017): 5282–94. https://doi.org/10.3748/wjg.v23.i29.5282.
Dimitroulis D, Damaskos C, Valsami S, Davakis S, Garmpis N, Spartalis E, et al. From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world. World journal of gastroenterology. 2017 Aug;23(29):5282–94.
Dimitroulis, Dimitrios, et al. “From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world.World Journal of Gastroenterology, vol. 23, no. 29, Aug. 2017, pp. 5282–94. Epmc, doi:10.3748/wjg.v23.i29.5282.
Dimitroulis D, Damaskos C, Valsami S, Davakis S, Garmpis N, Spartalis E, Athanasiou A, Moris D, Sakellariou S, Kykalos S, Tsourouflis G, Garmpi A, Delladetsima I, Kontzoglou K, Kouraklis G. From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world. World journal of gastroenterology. 2017 Aug;23(29):5282–5294.

Published In

World journal of gastroenterology

DOI

EISSN

2219-2840

ISSN

1007-9327

Publication Date

August 2017

Volume

23

Issue

29

Start / End Page

5282 / 5294

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Tobacco Smoking
  • Risk Factors
  • Prevalence
  • Practice Guidelines as Topic
  • Non-alcoholic Fatty Liver Disease
  • Neoplasm Staging
  • Liver Transplantation
  • Liver Neoplasms