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Surgical Management of Non-small Cell Lung Cancer with Solitary Hematogenous Metastases.

Publication ,  Journal Article
Karagkiouzis, G; Spartalis, E; Moris, D; Patsouras, D; Athanasiou, A; Karathanasis, I; Verveniotis, A; Konstantinou, F; Kouerinis, IA; Tomos, P ...
Published in: In vivo (Athens, Greece)
May 2017

The treatment of patients with solitary hematogenous metastases from non-small cell lung cancer (NSCLC) remains controversial, although numerous retrospective studies have reported favorable results for patients offered combined surgical therapy. Our aim was to determine the role of surgical resection in the management of NSCLC with solitary extrapulmonary metastases and to investigate for possible prognostic factors.Between January 2004 and December 2012, 12 patients with NSCLC, from two Institutions, underwent metastasectomy for their solitary metastatic lesion. Sites of metastases included brain (n=3), adrenal gland (n=6), thoracic wall (n=2) and diaphragm (n=1). All patients had undergone pulmonary resections for their primary NSCLC.Median survival for the entire cohort was 24.1 months, whereas 1- and 5-year survival rates were 73% and 39%, respectively. Patients with stage III intrathoracic disease had significantly worse survival than those with lower tumor stage. A tendency for adenocarcinomatous histology to positively affect survival was recognized, although it was proven not to be statistically significant.Despite the retrospective nature of our study and the small cohort size, it is emerging that combined surgical resection might offer patients with NSCLC with solitary hematogenous metastases a survival benefit. Limited intrathoracic disease and adenocarcinomatous histology might be associated with better outcomes.

Duke Scholars

Published In

In vivo (Athens, Greece)

DOI

EISSN

1791-7549

ISSN

0258-851X

Publication Date

May 2017

Volume

31

Issue

3

Start / End Page

451 / 454

Related Subject Headings

  • Survival Rate
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Metastasis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Hematologic Neoplasms
  • Carcinoma, Non-Small-Cell Lung
 

Citation

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Karagkiouzis, G., Spartalis, E., Moris, D., Patsouras, D., Athanasiou, A., Karathanasis, I., … Tomos, P. (2017). Surgical Management of Non-small Cell Lung Cancer with Solitary Hematogenous Metastases. In Vivo (Athens, Greece), 31(3), 451–454. https://doi.org/10.21873/invivo.11082
Karagkiouzis, Grigorios, Eleftherios Spartalis, Demetrios Moris, Demetrios Patsouras, Athanasios Athanasiou, Ioannis Karathanasis, Alexios Verveniotis, et al. “Surgical Management of Non-small Cell Lung Cancer with Solitary Hematogenous Metastases.In Vivo (Athens, Greece) 31, no. 3 (May 2017): 451–54. https://doi.org/10.21873/invivo.11082.
Karagkiouzis G, Spartalis E, Moris D, Patsouras D, Athanasiou A, Karathanasis I, et al. Surgical Management of Non-small Cell Lung Cancer with Solitary Hematogenous Metastases. In vivo (Athens, Greece). 2017 May;31(3):451–4.
Karagkiouzis, Grigorios, et al. “Surgical Management of Non-small Cell Lung Cancer with Solitary Hematogenous Metastases.In Vivo (Athens, Greece), vol. 31, no. 3, May 2017, pp. 451–54. Epmc, doi:10.21873/invivo.11082.
Karagkiouzis G, Spartalis E, Moris D, Patsouras D, Athanasiou A, Karathanasis I, Verveniotis A, Konstantinou F, Kouerinis IA, Potaris K, Dimitroulis D, Tomos P. Surgical Management of Non-small Cell Lung Cancer with Solitary Hematogenous Metastases. In vivo (Athens, Greece). 2017 May;31(3):451–454.

Published In

In vivo (Athens, Greece)

DOI

EISSN

1791-7549

ISSN

0258-851X

Publication Date

May 2017

Volume

31

Issue

3

Start / End Page

451 / 454

Related Subject Headings

  • Survival Rate
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Metastasis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Hematologic Neoplasms
  • Carcinoma, Non-Small-Cell Lung