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Novel biomarkers of abdominal aortic aneurysm disease: identifying gaps and dispelling misperceptions.

Publication ,  Journal Article
Moris, D; Mantonakis, E; Avgerinos, E; Makris, M; Bakoyiannis, C; Pikoulis, E; Georgopoulos, S
Published in: BioMed research international
January 2014

Abdominal aortic aneurysm (AAA) is a prevalent and potentially life-threatening disease. Early detection by screening programs and subsequent surveillance has been shown to be effective at reducing the risk of mortality due to aneurysm rupture. The aim of this review is to summarize the developments in the literature concerning the latest biomarkers (from 2008 to date) and their potential screening and therapeutic values. Our search included human studies in English and found numerous novel biomarkers under research, which were categorized in 6 groups. Most of these studies are either experimental or hampered by their low numbers of patients. We concluded that currently no specific laboratory markers allow screeing for the disease and monitoring its progression or the results of treatment. Further studies and studies in larger patient groups are required in order to validate biomarkers as cost-effective tools in the AAA disease.

Duke Scholars

Published In

BioMed research international

DOI

EISSN

2314-6141

ISSN

2314-6133

Publication Date

January 2014

Volume

2014

Start / End Page

925840

Related Subject Headings

  • Male
  • Humans
  • Female
  • Biomarkers
  • Aortic Aneurysm, Abdominal
  • 10 Technology
  • 08 Information and Computing Sciences
  • 06 Biological Sciences
 

Citation

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Moris, D., Mantonakis, E., Avgerinos, E., Makris, M., Bakoyiannis, C., Pikoulis, E., & Georgopoulos, S. (2014). Novel biomarkers of abdominal aortic aneurysm disease: identifying gaps and dispelling misperceptions. BioMed Research International, 2014, 925840. https://doi.org/10.1155/2014/925840
Moris, Demetrios, Eleftherios Mantonakis, Efthymios Avgerinos, Marinos Makris, Chris Bakoyiannis, Emmanuel Pikoulis, and Sotirios Georgopoulos. “Novel biomarkers of abdominal aortic aneurysm disease: identifying gaps and dispelling misperceptions.BioMed Research International 2014 (January 2014): 925840. https://doi.org/10.1155/2014/925840.
Moris D, Mantonakis E, Avgerinos E, Makris M, Bakoyiannis C, Pikoulis E, et al. Novel biomarkers of abdominal aortic aneurysm disease: identifying gaps and dispelling misperceptions. BioMed research international. 2014 Jan;2014:925840.
Moris, Demetrios, et al. “Novel biomarkers of abdominal aortic aneurysm disease: identifying gaps and dispelling misperceptions.BioMed Research International, vol. 2014, Jan. 2014, p. 925840. Epmc, doi:10.1155/2014/925840.
Moris D, Mantonakis E, Avgerinos E, Makris M, Bakoyiannis C, Pikoulis E, Georgopoulos S. Novel biomarkers of abdominal aortic aneurysm disease: identifying gaps and dispelling misperceptions. BioMed research international. 2014 Jan;2014:925840.

Published In

BioMed research international

DOI

EISSN

2314-6141

ISSN

2314-6133

Publication Date

January 2014

Volume

2014

Start / End Page

925840

Related Subject Headings

  • Male
  • Humans
  • Female
  • Biomarkers
  • Aortic Aneurysm, Abdominal
  • 10 Technology
  • 08 Information and Computing Sciences
  • 06 Biological Sciences