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The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance).

Publication ,  Journal Article
Gajra, A; McCall, L; Muss, HB; Cohen, HJ; Jatoi, A; Ballman, KV; Partridge, AH; Sutton, L; Parker, BA; Magrinat, G; Klepin, HD; Lafky, JM; Hurria, A
Published in: J Geriatr Oncol
May 2018

OBJECTIVE: Chemotherapy preference refers to a patient's interest in receiving chemotherapy. This study examined whether chemotherapy preference was associated with toxicity, efficacy, quality of life (QoL), and functional outcomes during and after completion of adjuvant chemotherapy in older women with breast cancer. MATERIALS AND METHODS: This study is a secondary analysis of CALGB 49907, a randomized trial that compared standard adjuvant chemotherapy versus capecitabine in patients age 65 years or older with breast cancer. A subset of 145 patients completed a questionnaire to describe chemotherapy preference pre-treatment. The association of this pre-treatment preference with the patient's perception of self-health, predicted and actual QoL, patient- and professional-reported toxicity, mental health, self-rated function, and survival was studied during and after treatment. RESULTS: The median age of patients was 71 years and 47% had a high preference for chemotherapy. On baseline demographics, the low preference group had a higher proportion of white patients (95% vs. 78%, p = 0.004). Before treatment, low chemotherapy preference was associated with greater nausea/vomiting (p = 0.008). Mid-treatment, low preference was associated with lower QoL, worse social, emotional and physical function (all p ≤ 0.02) and worse nausea/vomiting, cancer symptoms and financial worries (all p < 0.05). The association noted mid-treatment, resolved after treatment completion except with financial worries which persisted at 24 months. Low preference was associated with higher rates of grade 3-5 adverse events (53% vs. 34%, p = 0.02) but was not associated with survival. CONCLUSIONS: Low chemotherapy preference prior to treatment initiation was associated with lower QoL, worse physical symptoms and self-rated function and more adverse events mid-treatment. There is no association of chemotherapy preference with survival.

Duke Scholars

Published In

J Geriatr Oncol

DOI

EISSN

1879-4076

Publication Date

May 2018

Volume

9

Issue

3

Start / End Page

221 / 227

Location

Netherlands

Related Subject Headings

  • Vomiting
  • Treatment Refusal
  • Surveys and Questionnaires
  • Quality of Life
  • Patient Preference
  • Nausea
  • Humans
  • Female
  • Decision Making
  • Chemotherapy, Adjuvant
 

Citation

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Chicago
ICMJE
MLA
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Gajra, A., McCall, L., Muss, H. B., Cohen, H. J., Jatoi, A., Ballman, K. V., … Hurria, A. (2018). The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance). J Geriatr Oncol, 9(3), 221–227. https://doi.org/10.1016/j.jgo.2018.02.003
Gajra, Ajeet, Linda McCall, Hyman B. Muss, Harvey J. Cohen, Aminah Jatoi, Karla V. Ballman, Ann H. Partridge, et al. “The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance).J Geriatr Oncol 9, no. 3 (May 2018): 221–27. https://doi.org/10.1016/j.jgo.2018.02.003.
Gajra A, McCall L, Muss HB, Cohen HJ, Jatoi A, Ballman KV, et al. The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance). J Geriatr Oncol. 2018 May;9(3):221–7.
Gajra, Ajeet, et al. “The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance).J Geriatr Oncol, vol. 9, no. 3, May 2018, pp. 221–27. Pubmed, doi:10.1016/j.jgo.2018.02.003.
Gajra A, McCall L, Muss HB, Cohen HJ, Jatoi A, Ballman KV, Partridge AH, Sutton L, Parker BA, Magrinat G, Klepin HD, Lafky JM, Hurria A. The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance). J Geriatr Oncol. 2018 May;9(3):221–227.
Journal cover image

Published In

J Geriatr Oncol

DOI

EISSN

1879-4076

Publication Date

May 2018

Volume

9

Issue

3

Start / End Page

221 / 227

Location

Netherlands

Related Subject Headings

  • Vomiting
  • Treatment Refusal
  • Surveys and Questionnaires
  • Quality of Life
  • Patient Preference
  • Nausea
  • Humans
  • Female
  • Decision Making
  • Chemotherapy, Adjuvant