Scholars@Duke publication: Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Publication , Journal Article

Liu, Y; Sethi, NS; Hinoue, T; Schneider, BG; Cherniack, AD; Sanchez-Vega, F; Seoane, JA; Farshidfar, F; Bowlby, R; Islam, M; Kim, J; Akbani, R ...

Published in: Cancer Cell

April 9, 2018

Published version (DOI) Link to item

We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated with mutations in POLE. Tumors with chromosomal instability were diverse, with gastroesophageal adenocarcinomas harboring fragmented genomes associated with genomic doubling and distinct mutational signatures. We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1.

Duke Scholars

Author Shannon Jones McCall Pathology

Author Quinn Ostrom Neurosurgery, Neuro-Oncology

Author Andrew Berchuck Obstetrics and Gynecology, Gynecologic Oncology

Author Darell Doty Bigner Neurosurgery

Author Jeffrey R. Marks Surgery, Surgical Sciences

Author Roger Edwin McLendon Pathology

Author Angeles Alvarez Secord Obstetrics and Gynecology, Gynecologic Oncology

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Published In

Cancer Cell

DOI

10.1016/j.ccell.2018.03.010

EISSN

1878-3686

Publication Date

April 9, 2018

Volume

Issue

Start / End Page

721 / 735.e8

Location

United States

Related Subject Headings

SOX9 Transcription Factor
RNA-Binding Proteins
Proto-Oncogene Proteins p21(ras)
Polymorphism, Single Nucleotide
Poly-ADP-Ribose Binding Proteins
Oncology & Carcinogenesis
Mutation
MutL Protein Homolog 1
Microsatellite Instability
Male

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APA

Chicago

ICMJE

MLA

NLM

Liu, Y., Sethi, N. S., Hinoue, T., Schneider, B. G., Cherniack, A. D., Sanchez-Vega, F., … Laird, P. W. (2018). Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell, 33(4), 721-735.e8. https://doi.org/10.1016/j.ccell.2018.03.010

Liu, Yang, Nilay S. Sethi, Toshinori Hinoue, Barbara G. Schneider, Andrew D. Cherniack, Francisco Sanchez-Vega, Jose A. Seoane, et al. “Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.” Cancer Cell 33, no. 4 (April 9, 2018): 721-735.e8. https://doi.org/10.1016/j.ccell.2018.03.010.

Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, et al. Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell. 2018 Apr 9;33(4):721-735.e8.

Liu, Yang, et al. “Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.” Cancer Cell, vol. 33, no. 4, Apr. 2018, pp. 721-735.e8. Pubmed, doi:10.1016/j.ccell.2018.03.010.

Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall SJ, Mishra L, Ojesina AI, Bullman S, Pedamallu CS, Lazar AJ, Sakai R, Cancer Genome Atlas Research Network, Thorsson V, Bass AJ, Laird PW. Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell. 2018 Apr 9;33(4):721-735.e8.

Published In

Cancer Cell

DOI

10.1016/j.ccell.2018.03.010

EISSN

1878-3686

Publication Date

April 9, 2018

Volume

Issue

Start / End Page

721 / 735.e8

Location

United States

Related Subject Headings

SOX9 Transcription Factor
RNA-Binding Proteins
Proto-Oncogene Proteins p21(ras)
Polymorphism, Single Nucleotide
Poly-ADP-Ribose Binding Proteins
Oncology & Carcinogenesis
Mutation
MutL Protein Homolog 1
Microsatellite Instability
Male