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Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report.

Publication ,  Journal Article
Walicke, P; Abosch, A; Asher, A; Barker, FG; Ghogawala, Z; Harbaugh, R; Jehi, L; Kestle, J; Koroshetz, W; Little, R; Rubin, D; Valadka, A ...
Published in: Neurosurgery
April 1, 2017

This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice. Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new "science of practice."

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Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

April 1, 2017

Volume

80

Issue

4

Start / End Page

505 / 514

Location

United States

Related Subject Headings

  • Research Design
  • Neurosurgical Procedures
  • Neurosurgery
  • Neurology & Neurosurgery
  • Humans
  • Guidelines as Topic
  • Clinical Trials as Topic
  • Biomedical Research
  • Academies and Institutes
  • 5202 Biological psychology
 

Citation

APA
Chicago
ICMJE
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Walicke, P., Abosch, A., Asher, A., Barker, F. G., Ghogawala, Z., Harbaugh, R., … Workshop Participants, . (2017). Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report. Neurosurgery, 80(4), 505–514. https://doi.org/10.1093/neuros/nyw133
Walicke, Patricia, Aviva Abosch, Anthony Asher, Fred G. Barker, Zoher Ghogawala, Robert Harbaugh, Lara Jehi, et al. “Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report.Neurosurgery 80, no. 4 (April 1, 2017): 505–14. https://doi.org/10.1093/neuros/nyw133.
Walicke P, Abosch A, Asher A, Barker FG, Ghogawala Z, Harbaugh R, et al. Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report. Neurosurgery. 2017 Apr 1;80(4):505–14.
Walicke, Patricia, et al. “Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report.Neurosurgery, vol. 80, no. 4, Apr. 2017, pp. 505–14. Pubmed, doi:10.1093/neuros/nyw133.
Walicke P, Abosch A, Asher A, Barker FG, Ghogawala Z, Harbaugh R, Jehi L, Kestle J, Koroshetz W, Little R, Rubin D, Valadka A, Wisniewski S, Chiocca EA, Workshop Participants. Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report. Neurosurgery. 2017 Apr 1;80(4):505–514.
Journal cover image

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

April 1, 2017

Volume

80

Issue

4

Start / End Page

505 / 514

Location

United States

Related Subject Headings

  • Research Design
  • Neurosurgical Procedures
  • Neurosurgery
  • Neurology & Neurosurgery
  • Humans
  • Guidelines as Topic
  • Clinical Trials as Topic
  • Biomedical Research
  • Academies and Institutes
  • 5202 Biological psychology