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Hemorrhagic cystitis after allogeneic bone marrow transplantation in children: clinical characteristics and outcome.

Publication ,  Journal Article
Hale, GA; Rochester, RJ; Heslop, HE; Krance, RA; Gingrich, JR; Benaim, E; Horwitz, EM; Cunningham, JM; Tong, X; Srivastava, DK; Leung, WH ...
Published in: Biol Blood Marrow Transplant
November 2003

Hemorrhagic cystitis (HC) is a well-documented adverse event experienced by patients undergoing hematopoietic stem cell transplantation. When severe, HC causes significant morbidity, leads to renal complications, prolongs hospitalization, increases health-care costs, and occasionally contributes to death. We retrospectively studied the medical records of 245 children undergoing an initial allogeneic bone marrow transplantation for malignant disease at St. Jude Children's Research Hospital between 1992 and 1999 to describe the clinical course of HC in all patients and to identify the risk factors for HC in this cohort. Conditioning regimens included cyclophosphamide, cytarabine, and total body irradiation. Grafts from unrelated or mismatched related donors were depleted of T lymphocytes, whereas matched sibling grafts were unmanipulated. All patients received cyclosporine as prophylaxis for graft-versus-host disease. Recipients of grafts from matched siblings also received pentoxifylline or short-course methotrexate. Severe HC developed in 27 patients (11.0%). The median duration of HC was 73 days (range, 5-619 days); 12 patients had ongoing HC at the time of death. In univariate analyses, patients were at increased risk of severe HC if they were male (P =.021) or had received T cell-depleted grafts (P =.017), grafts from unrelated donors (P =.021), a lower total nucleated cell dose (P =.032), or antithymocyte globulin (P =.0446). Multiple regression analysis revealed male sex (beta =.97; P =.027) and unrelated donor graft recipients (beta =.83; P =.039) to be significant factors.

Duke Scholars

Published In

Biol Blood Marrow Transplant

DOI

ISSN

1083-8791

Publication Date

November 2003

Volume

9

Issue

11

Start / End Page

698 / 705

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Tissue Donors
  • Risk Factors
  • Retrospective Studies
  • Neoplasms
  • Middle Aged
  • Lymphocyte Transfusion
  • Living Donors
  • Infant
 

Citation

APA
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ICMJE
MLA
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Hale, G. A., Rochester, R. J., Heslop, H. E., Krance, R. A., Gingrich, J. R., Benaim, E., … Handgretinger, R. (2003). Hemorrhagic cystitis after allogeneic bone marrow transplantation in children: clinical characteristics and outcome. Biol Blood Marrow Transplant, 9(11), 698–705. https://doi.org/10.1016/s1083-8791(03)00269-6
Hale, G. A., R. J. Rochester, H. E. Heslop, R. A. Krance, J. R. Gingrich, E. Benaim, E. M. Horwitz, et al. “Hemorrhagic cystitis after allogeneic bone marrow transplantation in children: clinical characteristics and outcome.Biol Blood Marrow Transplant 9, no. 11 (November 2003): 698–705. https://doi.org/10.1016/s1083-8791(03)00269-6.
Hale GA, Rochester RJ, Heslop HE, Krance RA, Gingrich JR, Benaim E, et al. Hemorrhagic cystitis after allogeneic bone marrow transplantation in children: clinical characteristics and outcome. Biol Blood Marrow Transplant. 2003 Nov;9(11):698–705.
Hale, G. A., et al. “Hemorrhagic cystitis after allogeneic bone marrow transplantation in children: clinical characteristics and outcome.Biol Blood Marrow Transplant, vol. 9, no. 11, Nov. 2003, pp. 698–705. Pubmed, doi:10.1016/s1083-8791(03)00269-6.
Hale GA, Rochester RJ, Heslop HE, Krance RA, Gingrich JR, Benaim E, Horwitz EM, Cunningham JM, Tong X, Srivastava DK, Leung WH, Woodard P, Bowman LC, Handgretinger R. Hemorrhagic cystitis after allogeneic bone marrow transplantation in children: clinical characteristics and outcome. Biol Blood Marrow Transplant. 2003 Nov;9(11):698–705.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

ISSN

1083-8791

Publication Date

November 2003

Volume

9

Issue

11

Start / End Page

698 / 705

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Tissue Donors
  • Risk Factors
  • Retrospective Studies
  • Neoplasms
  • Middle Aged
  • Lymphocyte Transfusion
  • Living Donors
  • Infant