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Host APOL1 genotype is independently associated with proteinuria in HIV infection.

Publication ,  Journal Article
Estrella, MM; Wyatt, CM; Pearce, CL; Li, M; Shlipak, MG; Aouizerat, BE; Gustafson, D; Cohen, MH; Gange, SJ; Kao, WHL; Parekh, RS
Published in: Kidney Int
October 2013

Proteinuria is associated with adverse clinical outcomes in HIV infection. Here we evaluated whether APOL1 risk alleles, previously associated with advanced kidney disease, are independently associated with proteinuria in HIV infection in a cross-sectional study of HIV-infected women in the Women's Interagency HIV Study. We estimated the percent difference in urine protein excretion and odds of proteinuria (≥200 mg/g) associated with two versus one or no APOL1 risk allele using linear and logistic regression, respectively. Of 1285 women successfully genotyped, 379 carried one and 80 carried two risk alleles. Proteinuria was present in 124 women, 78 of whom had proteinuria confirmed on a second sample. In women without prior AIDS, two risk alleles were independently associated with a 69% higher urine protein excretion (95% confidence interval (CI): 36, 108) and five-fold higher odds of proteinuria (95% CI: 2.45, 10.37) as compared with one or no risk allele. No association was found in women with prior AIDS. Analyses in which women with impaired kidney function were excluded and proteinuria was confirmed by a second urine sample yielded similar estimates. Thus, APOL1 risk alleles are associated with significant proteinuria in HIV-infected persons without prior clinical AIDS, independent of clinical factors traditionally associated with proteinuria. Trials are needed to determine whether APOL1 genotyping identifies individuals who could benefit from earlier intervention to prevent overt renal disease.

Duke Scholars

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

October 2013

Volume

84

Issue

4

Start / End Page

834 / 840

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Sensitivity and Specificity
  • Risk Factors
  • Proteinuria
  • Middle Aged
  • Logistic Models
  • Lipoproteins, HDL
  • Humans
  • HIV Infections
  • Genotype
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Estrella, M. M., Wyatt, C. M., Pearce, C. L., Li, M., Shlipak, M. G., Aouizerat, B. E., … Parekh, R. S. (2013). Host APOL1 genotype is independently associated with proteinuria in HIV infection. Kidney Int, 84(4), 834–840. https://doi.org/10.1038/ki.2013.203
Estrella, Michelle M., Christina M. Wyatt, C Leigh Pearce, Man Li, Michael G. Shlipak, Bradley E. Aouizerat, Deborah Gustafson, et al. “Host APOL1 genotype is independently associated with proteinuria in HIV infection.Kidney Int 84, no. 4 (October 2013): 834–40. https://doi.org/10.1038/ki.2013.203.
Estrella MM, Wyatt CM, Pearce CL, Li M, Shlipak MG, Aouizerat BE, et al. Host APOL1 genotype is independently associated with proteinuria in HIV infection. Kidney Int. 2013 Oct;84(4):834–40.
Estrella, Michelle M., et al. “Host APOL1 genotype is independently associated with proteinuria in HIV infection.Kidney Int, vol. 84, no. 4, Oct. 2013, pp. 834–40. Pubmed, doi:10.1038/ki.2013.203.
Estrella MM, Wyatt CM, Pearce CL, Li M, Shlipak MG, Aouizerat BE, Gustafson D, Cohen MH, Gange SJ, Kao WHL, Parekh RS. Host APOL1 genotype is independently associated with proteinuria in HIV infection. Kidney Int. 2013 Oct;84(4):834–840.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

October 2013

Volume

84

Issue

4

Start / End Page

834 / 840

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Sensitivity and Specificity
  • Risk Factors
  • Proteinuria
  • Middle Aged
  • Logistic Models
  • Lipoproteins, HDL
  • Humans
  • HIV Infections
  • Genotype