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Relationship between electronically measured medication adherence and vision-related quality of life in a cohort of patients with open-angle glaucoma.

Publication ,  Journal Article
Thompson, AC; Woolson, S; Olsen, MK; Danus, S; Bosworth, HB; Muir, KW
Published in: BMJ Open Ophthalmol
2018

OBJECTIVE: To investigate whether electronically measured medication adherence is associated with vision-related quality of life (VRQoL) in patients with open-angle glaucoma. METHODS AND ANALYSIS: This is a 3-year prospective cohort study of 79 subjects with open-angle glaucoma at a Veterans Affairs medical centre. Participants returned a medication event monitoring system (MEMS) for their glaucoma eye-drops and had at least two visits with glaucoma during the study period. Those taking less than 80% of prescribed glaucoma medication doses were considered to be non-adherent. Subjects were interviewed using the National Eye Institute's Visual Function Questionnaire-25 (VFQ-25) at baseline and after 3 years. RESULTS: Thirty per cent (n=24/79) of participants took less than 80% of prescribed doses of their glaucoma medications at baseline. Patients who did not adhere to their medications at baseline had lower mean composite VFQ-25 scores at baseline (70.66±20.50 vs 75.91±19.12, standardised mean difference=0.27) and after 3 years (71.68±21.93 vs 76.25±21.67, standardised mean difference=0.21). Visual acuity (P=0.03), but not visual field severity (P=0.13) or medication adherence (P=0.30), was significantly associated with composite VFQ-25 score in an adjusted model. CONCLUSIONS: Subjects who were non-adherent to their glaucoma medications at baseline as assessed by a MEMS device reported lower VRQoL than adherent subjects at baseline and after 3 years. However, visual acuity was significantly associated with VRQoL. Future studies should assess whether improved adherence to eye-drops impacts VRQoL in patients with glaucoma.

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Published In

BMJ Open Ophthalmol

DOI

EISSN

2397-3269

Publication Date

2018

Volume

3

Issue

1

Start / End Page

e000114

Location

England

Related Subject Headings

  • 3212 Ophthalmology and optometry
 

Citation

APA
Chicago
ICMJE
MLA
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Thompson, A. C., Woolson, S., Olsen, M. K., Danus, S., Bosworth, H. B., & Muir, K. W. (2018). Relationship between electronically measured medication adherence and vision-related quality of life in a cohort of patients with open-angle glaucoma. BMJ Open Ophthalmol, 3(1), e000114. https://doi.org/10.1136/bmjophth-2017-000114
Thompson, Atalie C., Sandra Woolson, Maren K. Olsen, Susanne Danus, Hayden B. Bosworth, and Kelly W. Muir. “Relationship between electronically measured medication adherence and vision-related quality of life in a cohort of patients with open-angle glaucoma.BMJ Open Ophthalmol 3, no. 1 (2018): e000114. https://doi.org/10.1136/bmjophth-2017-000114.
Thompson AC, Woolson S, Olsen MK, Danus S, Bosworth HB, Muir KW. Relationship between electronically measured medication adherence and vision-related quality of life in a cohort of patients with open-angle glaucoma. BMJ Open Ophthalmol. 2018;3(1):e000114.
Thompson, Atalie C., et al. “Relationship between electronically measured medication adherence and vision-related quality of life in a cohort of patients with open-angle glaucoma.BMJ Open Ophthalmol, vol. 3, no. 1, 2018, p. e000114. Pubmed, doi:10.1136/bmjophth-2017-000114.
Thompson AC, Woolson S, Olsen MK, Danus S, Bosworth HB, Muir KW. Relationship between electronically measured medication adherence and vision-related quality of life in a cohort of patients with open-angle glaucoma. BMJ Open Ophthalmol. 2018;3(1):e000114.

Published In

BMJ Open Ophthalmol

DOI

EISSN

2397-3269

Publication Date

2018

Volume

3

Issue

1

Start / End Page

e000114

Location

England

Related Subject Headings

  • 3212 Ophthalmology and optometry