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Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Publication ,  Journal Article
Taylor, AM; Shih, J; Ha, G; Gao, GF; Zhang, X; Berger, AC; Schumacher, SE; Wang, C; Hu, H; Liu, J; Lazar, AJ; Cherniack, AD; Beroukhim, R ...
Published in: Cancer Cell
April 9, 2018

Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of proliferation genes. Aneuploidy was anti-correlated with expression of immune signaling genes, due to decreased leukocyte infiltrates in high-aneuploidy samples. Chromosome arm-level alterations show cancer-specific patterns, including loss of chromosome arm 3p in squamous cancers. We applied genome engineering to delete 3p in lung cells, causing decreased proliferation rescued in part by chromosome 3 duplication. This study defines genomic and phenotypic correlates of cancer aneuploidy and provides an experimental approach to study chromosome arm aneuploidy.

Duke Scholars

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Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

April 9, 2018

Volume

33

Issue

4

Start / End Page

676 / 689.e3

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Oncology & Carcinogenesis
  • Mutation Rate
  • Humans
  • Genomics
  • Databases, Genetic
  • Chromosomes, Human, Pair 3
  • Chromosome Deletion
  • Chromosome Aberrations
  • Cell Proliferation
 

Citation

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Taylor, A. M., Shih, J., Ha, G., Gao, G. F., Zhang, X., Berger, A. C., … Meyerson, M. (2018). Genomic and Functional Approaches to Understanding Cancer Aneuploidy. Cancer Cell, 33(4), 676-689.e3. https://doi.org/10.1016/j.ccell.2018.03.007
Taylor, Alison M., Juliann Shih, Gavin Ha, Galen F. Gao, Xiaoyang Zhang, Ashton C. Berger, Steven E. Schumacher, et al. “Genomic and Functional Approaches to Understanding Cancer Aneuploidy.Cancer Cell 33, no. 4 (April 9, 2018): 676-689.e3. https://doi.org/10.1016/j.ccell.2018.03.007.
Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, et al. Genomic and Functional Approaches to Understanding Cancer Aneuploidy. Cancer Cell. 2018 Apr 9;33(4):676-689.e3.
Taylor, Alison M., et al. “Genomic and Functional Approaches to Understanding Cancer Aneuploidy.Cancer Cell, vol. 33, no. 4, Apr. 2018, pp. 676-689.e3. Pubmed, doi:10.1016/j.ccell.2018.03.007.
Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, Schumacher SE, Wang C, Hu H, Liu J, Lazar AJ, Cancer Genome Atlas Research Network, Cherniack AD, Beroukhim R, Meyerson M. Genomic and Functional Approaches to Understanding Cancer Aneuploidy. Cancer Cell. 2018 Apr 9;33(4):676-689.e3.
Journal cover image

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

April 9, 2018

Volume

33

Issue

4

Start / End Page

676 / 689.e3

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Oncology & Carcinogenesis
  • Mutation Rate
  • Humans
  • Genomics
  • Databases, Genetic
  • Chromosomes, Human, Pair 3
  • Chromosome Deletion
  • Chromosome Aberrations
  • Cell Proliferation