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Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment.

Publication ,  Journal Article
Hockenberry, MJ; Moore, IMK; Scheurer, ME; Hooke, MC; Taylor, OA; Koerner, KM; Gundy, PM; Pan, W
Published in: Biological research for nursing
July 2018

The focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reductions. Compromise in therapy can negatively influence the quality of life and, even more notably, jeopardize chances for long-term survival. This study examined biologic mechanisms that influence fatigue caused by increased reactive oxidative species (ROS) or actual failure of the antioxidant defense system due to genetic variation by investigating reactive nitrosative species, a "downstream" consequence of ROS. The specific aims of this study were to characterize the trajectory of nitrosative stress during acute lymphoblastic leukemia treatment and evaluate the influence of nitrosative stress on fatigue. A repeated measures design was used to evaluate the fatigue experienced by 186 children and adolescents, 3-18 years of age, with a diagnosis of leukemia during the most intense phase of treatment. An established biomarker of nitrosative stress, protein 3-nitrotyrosine (3NT) residues in the cerebral spinal fluid, was evaluated at diagnosis, postinduction, and consolidation phases of treatment. Higher fatigue was associated with higher 3NT levels at the beginning of treatment. Two distinct groups of children experienced either consistently high or consistently low 3NT levels across the treatment trajectory, from diagnosis to 12 months postinduction. Findings from this study support continued exploration into the phenotypic biochemical mechanisms that influence a reactive response to childhood cancer treatment.

Duke Scholars

Published In

Biological research for nursing

DOI

EISSN

1552-4175

ISSN

1099-8004

Publication Date

July 2018

Volume

20

Issue

4

Start / End Page

403 / 409

Related Subject Headings

  • Tyrosine
  • Quality of Life
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oxidative Stress
  • Nursing
  • Nitrosative Stress
  • Male
  • Longitudinal Studies
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Hockenberry, M. J., Moore, I. M. K., Scheurer, M. E., Hooke, M. C., Taylor, O. A., Koerner, K. M., … Pan, W. (2018). Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment. Biological Research for Nursing, 20(4), 403–409. https://doi.org/10.1177/1099800418772907
Hockenberry, Marilyn J., Ida M Ki Moore, Michael E. Scheurer, Mary C. Hooke, Olga A. Taylor, Kari M. Koerner, Patricia M. Gundy, and Wei Pan. “Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment.Biological Research for Nursing 20, no. 4 (July 2018): 403–9. https://doi.org/10.1177/1099800418772907.
Hockenberry MJ, Moore IMK, Scheurer ME, Hooke MC, Taylor OA, Koerner KM, et al. Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment. Biological research for nursing. 2018 Jul;20(4):403–9.
Hockenberry, Marilyn J., et al. “Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment.Biological Research for Nursing, vol. 20, no. 4, July 2018, pp. 403–09. Epmc, doi:10.1177/1099800418772907.
Hockenberry MJ, Moore IMK, Scheurer ME, Hooke MC, Taylor OA, Koerner KM, Gundy PM, Pan W. Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment. Biological research for nursing. 2018 Jul;20(4):403–409.
Journal cover image

Published In

Biological research for nursing

DOI

EISSN

1552-4175

ISSN

1099-8004

Publication Date

July 2018

Volume

20

Issue

4

Start / End Page

403 / 409

Related Subject Headings

  • Tyrosine
  • Quality of Life
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oxidative Stress
  • Nursing
  • Nitrosative Stress
  • Male
  • Longitudinal Studies
  • Humans
  • Female