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The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study.

Publication ,  Journal Article
Turner, DA; Khioe, RFS; Shepstone, L; Lenaghan, E; Cooper, C; Gittoes, N; Harvey, NC; Holland, R; Howe, A; McCloskey, E; O'Neill, TW ...
Published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
May 2018

The SCOOP study was a two-arm randomized controlled trial conducted in the UK in 12,483 eligible women aged 70 to 85 years. It compared a screening program using the FRAX® risk assessment tool in addition to bone mineral density (BMD) measures versus usual management. The SCOOP study found a reduction in the incidence of hip fractures in the screening arm, but there was no evidence of a reduction in the incidence of all osteoporosis-related fractures. To make decisions about whether to implement any screening program, we should also consider whether the program is likely to be a good use of health care resources, ie, is it cost-effective? The cost per gained quality adjusted life year of screening for fracture risk has not previously been demonstrated in an economic evaluation alongside a clinical trial. We conducted a "within trial" economic analysis alongside the SCOOP study from the perspective of a national health payer, the UK National Health Service (NHS). The main outcome measure in the economic analysis was the cost per quality adjusted life year (QALY) gained over a 5-year time period. We also estimated cost per osteoporosis-related fracture prevented and the cost per hip fracture prevented. The screening arm had an average incremental QALY gain of 0.0237 (95% confidence interval -0.0034 to 0.0508) for the 5-year follow-up. The incremental cost per QALY gained was £2772 compared with the control arm. Cost-effectiveness acceptability curves indicated a 93% probability of the intervention being cost-effective at values of a QALY greater than £20,000. The intervention arm prevented fractures at a cost of £4478 and £7694 per fracture for osteoporosis-related and hip fractures, respectively. The current study demonstrates that a systematic, community-based screening program of fracture risk in older women in the UK represents a highly cost-effective intervention. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc.

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Published In

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

DOI

EISSN

1523-4681

ISSN

0884-0431

Publication Date

May 2018

Volume

33

Issue

5

Start / End Page

845 / 851

Related Subject Headings

  • Osteoporosis
  • Mass Screening
  • Humans
  • Fractures, Bone
  • Follow-Up Studies
  • Female
  • Costs and Cost Analysis
  • Bone Density
  • Anatomy & Morphology
  • Aged, 80 and over
 

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Turner, D. A., Khioe, R. F. S., Shepstone, L., Lenaghan, E., Cooper, C., Gittoes, N., … SCOOP Study Team, . (2018). The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research, 33(5), 845–851. https://doi.org/10.1002/jbmr.3381
Turner, David A., Rebekah Fong Soe Khioe, Lee Shepstone, Elizabeth Lenaghan, Cyrus Cooper, Neil Gittoes, Nicholas C. Harvey, et al. “The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study.Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research 33, no. 5 (May 2018): 845–51. https://doi.org/10.1002/jbmr.3381.
Turner DA, Khioe RFS, Shepstone L, Lenaghan E, Cooper C, Gittoes N, et al. The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2018 May;33(5):845–51.
Turner, David A., et al. “The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study.Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research, vol. 33, no. 5, May 2018, pp. 845–51. Epmc, doi:10.1002/jbmr.3381.
Turner DA, Khioe RFS, Shepstone L, Lenaghan E, Cooper C, Gittoes N, Harvey NC, Holland R, Howe A, McCloskey E, O’Neill TW, Torgerson D, Fordham R, SCOOP Study Team. The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2018 May;33(5):845–851.
Journal cover image

Published In

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

DOI

EISSN

1523-4681

ISSN

0884-0431

Publication Date

May 2018

Volume

33

Issue

5

Start / End Page

845 / 851

Related Subject Headings

  • Osteoporosis
  • Mass Screening
  • Humans
  • Fractures, Bone
  • Follow-Up Studies
  • Female
  • Costs and Cost Analysis
  • Bone Density
  • Anatomy & Morphology
  • Aged, 80 and over