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Increased plasma complement factor H is associated with geriatric depression.

Publication ,  Journal Article
Shin, C; Ham, B-J; Ko, Y-H; Pae, C-U; Park, MH; Steffens, DC; Patkar, AA; Han, C
Published in: Int Psychogeriatr
January 2019

UNLABELLED: ABSTRACTBackground:Complement factor H (CFH) plays a key role in regulating the cascade of the alternative pathway of the complement system. Dysregulation of CFH may be involved in the pathophysiology of various inflammation-mediated diseases including neuropsychiatric illnesses. This study aimed to investigate this relationship by examining determining CFH levels in elderly individuals with and without depression. METHODS: A total of 152 elderly individuals (major depressive disorder (MDD) group, n = 76; comparison sample, n = 76) were selected from the Ansan Geriatric study. The plasma level of CFH was measured. MDD was diagnosed with the Mini-International Neuropsychiatric Interview as per DSM-IV criteria. The severity of depression was evaluated with the geriatric depression scale (GDS). Mean CFH levels were compared using the Mann-Whitney U test. After adjusting for possible confounding factors including age, sex, marital status, education, alcohol use, hemoglobin levels, and the Korean version of the Mini-Mental State Examination (MMSE-KC), a multiple regression analysis was conducted. The GDS score and plasma level of CFH were analyzed using Spearman's correlation. RESULTS: Plasma CFH level was significantly higher in individuals with MDD than in the comparison sample (289.51 ± 21.16 vs. 339.67 ± 66.23, p < 0.001). In a regression model adjusted for possible confounders, CFH was significantly associated with geriatric depression (p < 0.001). CFH levels were not significantly related to GDS scores in the depressed group. CONCLUSION: This study revealed an association between high plasma levels of CFH and geriatric depression, thereby suggesting the alternative pathway of the complement system contributing to the development of geriatric depression.

Duke Scholars

Published In

Int Psychogeriatr

DOI

EISSN

1741-203X

Publication Date

January 2019

Volume

31

Issue

1

Start / End Page

101 / 108

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Republic of Korea
  • Psychiatric Status Rating Scales
  • Prospective Studies
  • Multivariate Analysis
  • Male
  • Logistic Models
  • Humans
  • Geriatrics
  • Geriatric Assessment
 

Citation

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Shin, C., Ham, B.-J., Ko, Y.-H., Pae, C.-U., Park, M. H., Steffens, D. C., … Han, C. (2019). Increased plasma complement factor H is associated with geriatric depression. Int Psychogeriatr, 31(1), 101–108. https://doi.org/10.1017/S1041610218000558
Shin, Cheolmin, Byung-Joo Ham, Young-Hoon Ko, Chi-Un Pae, Moon Ho Park, David C. Steffens, Ashwin A. Patkar, and Changsu Han. “Increased plasma complement factor H is associated with geriatric depression.Int Psychogeriatr 31, no. 1 (January 2019): 101–8. https://doi.org/10.1017/S1041610218000558.
Shin C, Ham B-J, Ko Y-H, Pae C-U, Park MH, Steffens DC, et al. Increased plasma complement factor H is associated with geriatric depression. Int Psychogeriatr. 2019 Jan;31(1):101–8.
Shin, Cheolmin, et al. “Increased plasma complement factor H is associated with geriatric depression.Int Psychogeriatr, vol. 31, no. 1, Jan. 2019, pp. 101–08. Pubmed, doi:10.1017/S1041610218000558.
Shin C, Ham B-J, Ko Y-H, Pae C-U, Park MH, Steffens DC, Patkar AA, Han C. Increased plasma complement factor H is associated with geriatric depression. Int Psychogeriatr. 2019 Jan;31(1):101–108.
Journal cover image

Published In

Int Psychogeriatr

DOI

EISSN

1741-203X

Publication Date

January 2019

Volume

31

Issue

1

Start / End Page

101 / 108

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Republic of Korea
  • Psychiatric Status Rating Scales
  • Prospective Studies
  • Multivariate Analysis
  • Male
  • Logistic Models
  • Humans
  • Geriatrics
  • Geriatric Assessment