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Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum.

Publication ,  Journal Article
Foster, WG; Holloway, AC; Hughes, CL
Published in: Am J Obstet Gynecol
December 2005

OBJECTIVE: Developmental exposure to dioxin-like compounds has been associated with cognitive and motor impairments in children. These toxicants have been shown to be thyroid toxicants in animal studies. Therefore, the objective of this study was to quantify the overall dioxin-like activity in maternal serum and determine the association between dioxin-like activity and thyroid hormone levels. STUDY DESIGN: Cross-sectional examination of serum from pregnant women (n = 150) attending a prenatal diagnosis clinic between January 2002 and December 2003. RESULTS: Serum dioxin-like activity was measured in 145 of 150 (96.7%) maternal serum samples. The mean (+/- SEM) serum lipid-adjusted dioxin-like activity was 0.34 +/- 0.01 pg/g. Multiple regression analysis failed to demonstrate a relationship between maternal serum dioxin-like activity and serum thyroid hormone levels. CONCLUSION: Dioxin-like activity is quantifiable in an overwhelming majority of second-trimester maternal serum samples but there was no relationship between dioxin-like activity and thyroid hormone levels in our study population.

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Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

December 2005

Volume

193

Issue

6

Start / End Page

1900 / 1907

Location

United States

Related Subject Headings

  • Thyroxine
  • Thyrotropin
  • Thyroid Hormones
  • Smoking
  • Radioimmunoassay
  • Pregnancy Trimester, Second
  • Pregnancy
  • Polychlorinated Biphenyls
  • Obstetrics & Reproductive Medicine
  • Life Style
 

Citation

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Foster, W. G., Holloway, A. C., & Hughes, C. L. (2005). Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum. Am J Obstet Gynecol, 193(6), 1900–1907. https://doi.org/10.1016/j.ajog.2005.08.013
Foster, Warren G., Alison C. Holloway, and Claude L. Hughes. “Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum.Am J Obstet Gynecol 193, no. 6 (December 2005): 1900–1907. https://doi.org/10.1016/j.ajog.2005.08.013.
Foster WG, Holloway AC, Hughes CL. Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum. Am J Obstet Gynecol. 2005 Dec;193(6):1900–7.
Foster, Warren G., et al. “Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum.Am J Obstet Gynecol, vol. 193, no. 6, Dec. 2005, pp. 1900–07. Pubmed, doi:10.1016/j.ajog.2005.08.013.
Foster WG, Holloway AC, Hughes CL. Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum. Am J Obstet Gynecol. 2005 Dec;193(6):1900–1907.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

December 2005

Volume

193

Issue

6

Start / End Page

1900 / 1907

Location

United States

Related Subject Headings

  • Thyroxine
  • Thyrotropin
  • Thyroid Hormones
  • Smoking
  • Radioimmunoassay
  • Pregnancy Trimester, Second
  • Pregnancy
  • Polychlorinated Biphenyls
  • Obstetrics & Reproductive Medicine
  • Life Style