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An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment.

Publication ,  Journal Article
vom Saal, FS; Hughes, C
Published in: Environ Health Perspect
August 2005

Bisphenol A (BPA) is the monomer used to manufacture polycarbonate plastic, the resin lining of cans, and other products, with global capacity in excess of 6.4 billion lb/year. Because the ester bonds in these BPA-based polymers are subject to hydrolysis, leaching of BPA has led to widespread human exposure. A recent report prepared by the Harvard Center for Risk Analysis and funded by the American Plastics Council concluded that evidence for low-dose effects of BPA is weak on the basis of a review of only 19 studies; the report was issued after a delay of 2.5 years. A current comprehensive review of the literature reveals that the opposite is true. As of December 2004, there were 115 published in vivo studies concerning low-dose effects of BPA, and 94 of these report significant effects. In 31 publications with vertebrate and invertebrate animals, significant effects occurred below the predicted "safe" or reference dose of 50 microg/kg/day BPA. An estrogenic mode of action of BPA is confirmed by in vitro experiments, which describe disruption of cell function at 10(-12) M or 0.23 ppt. Nonetheless, chemical manufacturers continue to discount these published findings because no industry-funded studies have reported significant effects of low doses of BPA, although > 90% of government-funded studies have reported significant effects. Some industry-funded studies have ignored the results of positive controls, and many studies reporting no significant effects used a strain of rat that is inappropriate for the study of estrogenic responses. We propose that a new risk assessment for BPA is needed based on a) the extensive new literature reporting adverse effects in animals at doses below the current reference dose; b) the high rate of leaching of BPA from food and beverage containers, leading to widespread human exposure; c) reports that the median BPA level in human blood and tissues, including in human fetal blood, is higher than the level that causes adverse effects in mice; and d) recent epidemiologic evidence that BPA is related to disease in women.

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Published In

Environ Health Perspect

DOI

ISSN

0091-6765

Publication Date

August 2005

Volume

113

Issue

8

Start / End Page

926 / 933

Location

United States

Related Subject Headings

  • Toxicology
  • Risk Assessment
  • Phenols
  • Humans
  • Estrogens, Non-Steroidal
  • Environmental Pollutants
  • Environmental Exposure
  • Dose-Response Relationship, Drug
  • Benzhydryl Compounds
  • Animals
 

Citation

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vom Saal, F. S., & Hughes, C. (2005). An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. Environ Health Perspect, 113(8), 926–933. https://doi.org/10.1289/ehp.7713
Saal, Frederick S. vom, and Claude Hughes. “An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment.Environ Health Perspect 113, no. 8 (August 2005): 926–33. https://doi.org/10.1289/ehp.7713.
vom Saal, Frederick S., and Claude Hughes. “An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment.Environ Health Perspect, vol. 113, no. 8, Aug. 2005, pp. 926–33. Pubmed, doi:10.1289/ehp.7713.
vom Saal FS, Hughes C. An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. Environ Health Perspect. 2005 Aug;113(8):926–933.

Published In

Environ Health Perspect

DOI

ISSN

0091-6765

Publication Date

August 2005

Volume

113

Issue

8

Start / End Page

926 / 933

Location

United States

Related Subject Headings

  • Toxicology
  • Risk Assessment
  • Phenols
  • Humans
  • Estrogens, Non-Steroidal
  • Environmental Pollutants
  • Environmental Exposure
  • Dose-Response Relationship, Drug
  • Benzhydryl Compounds
  • Animals