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Relationship of meeting physical activity guidelines with quality-adjusted life-years.

Publication ,  Journal Article
Sun, K; Song, J; Manheim, LM; Chang, RW; Kwoh, KC; Semanik, PA; Eaton, CB; Dunlop, DD
Published in: Semin Arthritis Rheum
December 2014

OBJECTIVE: The quality-adjusted life-year (QALY) is a standard outcome measure used in cost-effectiveness analyses. This study investigates whether attainment of federal physical activity guidelines is associated with higher QALY estimates among adults with or at an increased risk for knee osteoarthritis. METHODS: This is a prospective study of 1794 Osteoarthritis Initiative participants. Physical activity was measured using accelerometers at baseline. Participants were classified as (1) Meeting Guidelines [≥150min of moderate-to-vigorous (MV) activity per week acquired in sessions ≥10min], (2) Insufficiently Active (≥1 MV session[s]/week but below the guideline), or (3) Inactive (zero MV sessions/week). A health-related utility score was derived from participant responses to the 12-item Short-Form Health Survey at baseline and 2 years later. The QALY was calculated as the area under utility curve over 2 years. The relationship of physical activity level to median QALY adjusted for socioeconomic and health factors was estimated using quantile regression. RESULTS: Relative to the Inactive group, median QALYs over 2 years were significantly higher for the Meeting Guidelines (0.112, 95% CI: 0.067-0.157) and Insufficiently Active (0.058, 95% CI: 0.028-0.088) groups, controlling for socioeconomic and health factors. CONCLUSION: We found a significant graded relationship between greater physical activity level and higher QALYs. Using the more conservative estimate of 0.058, if an intervention could move someone out of the Inactive group and costs <$2900 over 2 years, it would be considered cost effective. Our analysis supports interventions to promote physical activity even if recommended levels are not fully attained.

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Published In

Semin Arthritis Rheum

DOI

EISSN

1532-866X

Publication Date

December 2014

Volume

44

Issue

3

Start / End Page

264 / 270

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Risk Factors
  • Regression Analysis
  • Quality-Adjusted Life Years
  • Prospective Studies
  • Outcome Assessment, Health Care
  • Osteoarthritis, Knee
  • Motor Activity
  • Middle Aged
  • Male
 

Citation

APA
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ICMJE
MLA
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Sun, K., Song, J., Manheim, L. M., Chang, R. W., Kwoh, K. C., Semanik, P. A., … Dunlop, D. D. (2014). Relationship of meeting physical activity guidelines with quality-adjusted life-years. Semin Arthritis Rheum, 44(3), 264–270. https://doi.org/10.1016/j.semarthrit.2014.06.002
Sun, Kai, Jing Song, Larry M. Manheim, Rowland W. Chang, Kent C. Kwoh, Pamela A. Semanik, Charles B. Eaton, and Dorothy D. Dunlop. “Relationship of meeting physical activity guidelines with quality-adjusted life-years.Semin Arthritis Rheum 44, no. 3 (December 2014): 264–70. https://doi.org/10.1016/j.semarthrit.2014.06.002.
Sun K, Song J, Manheim LM, Chang RW, Kwoh KC, Semanik PA, et al. Relationship of meeting physical activity guidelines with quality-adjusted life-years. Semin Arthritis Rheum. 2014 Dec;44(3):264–70.
Sun, Kai, et al. “Relationship of meeting physical activity guidelines with quality-adjusted life-years.Semin Arthritis Rheum, vol. 44, no. 3, Dec. 2014, pp. 264–70. Pubmed, doi:10.1016/j.semarthrit.2014.06.002.
Sun K, Song J, Manheim LM, Chang RW, Kwoh KC, Semanik PA, Eaton CB, Dunlop DD. Relationship of meeting physical activity guidelines with quality-adjusted life-years. Semin Arthritis Rheum. 2014 Dec;44(3):264–270.
Journal cover image

Published In

Semin Arthritis Rheum

DOI

EISSN

1532-866X

Publication Date

December 2014

Volume

44

Issue

3

Start / End Page

264 / 270

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Risk Factors
  • Regression Analysis
  • Quality-Adjusted Life Years
  • Prospective Studies
  • Outcome Assessment, Health Care
  • Osteoarthritis, Knee
  • Motor Activity
  • Middle Aged
  • Male