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Relation of Early Repolarization (J Point Elevation) to Mortality in Blacks (from the Jackson Heart Study).

Publication ,  Journal Article
Kelly, JP; Greiner, M; Soliman, EZ; Randolph, TC; Thomas, KL; Dunlay, SM; Curtis, LH; O'Brien, EC; Mentz, RJ
Published in: Am J Cardiol
July 15, 2018

Conflicting data exist regarding the associations of early repolarization (ER) with electrocardiogram (ECG) and clinical outcomes in blacks. We examined the association of ER defined by J point elevation (JPE) and all-cause mortality, and heart failure (HF) hospitalization in blacks in the Jackson Heart Study (JHS) cohort. We included JHS participants with ECGs from the baseline visit coding JPE and excluded participants with paced rhythms or QRS duration ≥120 ms. We compared the cumulative incidence of 10-year all-cause mortality and 8-year HF hospitalization by presence of JPE ≥0.1 mV in any ECG lead at baseline using Kaplan-Meier estimates and multivariable Cox models. Of the 4,978 participants, 1,410 (28%) had JPE at baseline: anterior leads 97.8%, lateral leads 8.3%, and inferior leads 2.9%. Compared with participants without JPE, those with JPE were younger, more likely to be male and current smokers, and less likely to have hypertension. Over a median follow-up of 8 years, there were no significant differences in the cumulative incidence or multivariable-adjusted hazards of all-cause mortality or HF hospitalization in participants with and without JPE in any lead (adjusted hazard ratio 0.97, 95% confidence interval 0.89 to 1.52, and adjusted hazard ratio 1.18, 95% confidence interval 0.9 to 1.54, respectively). Of the 2,523 participants who completed Exam 3 without JPE at baseline, 246 (10%) developed JPE over follow-up. In conclusion, JPE on ECG was not associated with long-term mortality or HF hospitalization in a large prospective black community cohort, suggesting that ER may represent a benign ECG finding in blacks.

Duke Scholars

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

July 15, 2018

Volume

122

Issue

2

Start / End Page

340 / 346

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Survival Rate
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Longitudinal Studies
 

Citation

APA
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MLA
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Kelly, J. P., Greiner, M., Soliman, E. Z., Randolph, T. C., Thomas, K. L., Dunlay, S. M., … Mentz, R. J. (2018). Relation of Early Repolarization (J Point Elevation) to Mortality in Blacks (from the Jackson Heart Study). Am J Cardiol, 122(2), 340–346. https://doi.org/10.1016/j.amjcard.2018.04.004
Kelly, Jacob P., Melissa Greiner, Elsayed Z. Soliman, Tiffany C. Randolph, Kevin L. Thomas, Shannon M. Dunlay, Lesley H. Curtis, Emily C. O’Brien, and Robert J. Mentz. “Relation of Early Repolarization (J Point Elevation) to Mortality in Blacks (from the Jackson Heart Study).Am J Cardiol 122, no. 2 (July 15, 2018): 340–46. https://doi.org/10.1016/j.amjcard.2018.04.004.
Kelly JP, Greiner M, Soliman EZ, Randolph TC, Thomas KL, Dunlay SM, et al. Relation of Early Repolarization (J Point Elevation) to Mortality in Blacks (from the Jackson Heart Study). Am J Cardiol. 2018 Jul 15;122(2):340–6.
Kelly, Jacob P., et al. “Relation of Early Repolarization (J Point Elevation) to Mortality in Blacks (from the Jackson Heart Study).Am J Cardiol, vol. 122, no. 2, July 2018, pp. 340–46. Pubmed, doi:10.1016/j.amjcard.2018.04.004.
Kelly JP, Greiner M, Soliman EZ, Randolph TC, Thomas KL, Dunlay SM, Curtis LH, O’Brien EC, Mentz RJ. Relation of Early Repolarization (J Point Elevation) to Mortality in Blacks (from the Jackson Heart Study). Am J Cardiol. 2018 Jul 15;122(2):340–346.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

July 15, 2018

Volume

122

Issue

2

Start / End Page

340 / 346

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Survival Rate
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Longitudinal Studies