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Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.

Publication ,  Journal Article
Hong, JC; Cui, Y; Patel, BN; Rushing, CN; Faught, AM; Eng, JS; Higgins, K; Yin, F-F; Das, S; Czito, BG; Willett, CG; Palta, M
Published in: Int J Radiat Oncol Biol Phys
November 15, 2018

PURPOSE: Imaging parameters from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) before and after chemoradiation therapy (CRT) for anal canal cancer correlate with clinical outcomes. This prospective, hypothesis-generating pilot study investigates the relationship between interim PET imaging during CRT for anal canal cancer and clinical outcome. METHODS AND MATERIALS: From June 2012 to August 2015, 30 patients with anal canal cancer were enrolled in a prospective clinical study of PET prior to and during CRT after ∼30 Gy. PET parameters of the primary site included maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). MTV and TLG were calculated based on 40% SUVmax (MTV40, TLG40) or SUV 2.5 (MTV2.5, TLG2.5) thresholds for pretreatment and interim images. Absolute and change in PET parameters were assessed for association with freedom from local and regional recurrence (FFLR) using single-predictor Cox regression models. Local and regional recurrence were primary and nodal (in-field) recurrences, respectively. RESULTS: Twenty-three patients were eligible for analysis. Patients were excluded with nonsquamous cell histology, recurrent anal cancer, and incomplete studies due to treatment toxicity or patient choice. Median follow-up was 2.5 years. Pretreatment MTV40 (HR 1.4 [95% CI 1.02-2.05]), interim MTV2.5 (1.4 [1.04-1.89]), and interim TLG2.5 (1.1 [1.01-1.21]) were associated with FFLR. CONCLUSIONS: In this prospective pilot study, interim PET parameters were associated with FFLR. These results warrant further investigation assessing the value of interim PET as a biomarker of response in the treatment of patients with anal cancer.

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Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

November 15, 2018

Volume

102

Issue

4

Start / End Page

1046 / 1051

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Recurrence
  • Positron Emission Tomography Computed Tomography
  • Pilot Projects
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Fluorodeoxyglucose F18
  • Female
 

Citation

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Hong, J. C., Cui, Y., Patel, B. N., Rushing, C. N., Faught, A. M., Eng, J. S., … Palta, M. (2018). Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence. Int J Radiat Oncol Biol Phys, 102(4), 1046–1051. https://doi.org/10.1016/j.ijrobp.2018.04.062
Hong, Julian C., Yunfeng Cui, Bhavik N. Patel, Christel N. Rushing, Austin M. Faught, Jared S. Eng, Kyle Higgins, et al. “Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.Int J Radiat Oncol Biol Phys 102, no. 4 (November 15, 2018): 1046–51. https://doi.org/10.1016/j.ijrobp.2018.04.062.
Hong JC, Cui Y, Patel BN, Rushing CN, Faught AM, Eng JS, et al. Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1046–51.
Hong, Julian C., et al. “Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.Int J Radiat Oncol Biol Phys, vol. 102, no. 4, Nov. 2018, pp. 1046–51. Pubmed, doi:10.1016/j.ijrobp.2018.04.062.
Hong JC, Cui Y, Patel BN, Rushing CN, Faught AM, Eng JS, Higgins K, Yin F-F, Das S, Czito BG, Willett CG, Palta M. Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1046–1051.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

November 15, 2018

Volume

102

Issue

4

Start / End Page

1046 / 1051

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Recurrence
  • Positron Emission Tomography Computed Tomography
  • Pilot Projects
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Fluorodeoxyglucose F18
  • Female