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At the Atrioventricular Crossroads: Dual Pathway Electrophysiology in the Atrioventricular Node and its Underlying Heterogeneities.

Publication ,  Journal Article
George, SA; Faye, NR; Murillo-Berlioz, A; Lee, KB; Trachiotis, GD; Efimov, IR
Published in: Arrhythmia & electrophysiology review
December 2017

The atrioventricular node (AVN) is a complex structure that performs a variety of functions in the heart. The AVN is primarily an electrical gatekeeper between the atria and ventricles and introduces a delay between atrial and ventricular excitation, allowing for efficient ventricular filling. The AVN is composed of several compartments that safely transmit electrical excitation from the atria to the ventricles via the fast or slow pathways. There are many electrophysiological differences between these pathways, including conduction time and electrical refractoriness, that increase the predisposition of the atrioventricular junction to arrhythmias such as atrioventricular nodal re-entrant tachycardia. These varied electrophysiological characteristics of the fast and slow pathways stem from their unique structural and molecular composition (tissue and cellular geometry, ion channels and gap junctions). This review summarises the structural and molecular heterogeneities of the human AVN and how they result in electrophysiological variations and arrhythmias.

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Published In

Arrhythmia & electrophysiology review

DOI

EISSN

2050-3377

ISSN

2050-3369

Publication Date

December 2017

Volume

6

Issue

4

Start / End Page

179 / 185
 

Citation

APA
Chicago
ICMJE
MLA
NLM
George, S. A., Faye, N. R., Murillo-Berlioz, A., Lee, K. B., Trachiotis, G. D., & Efimov, I. R. (2017). At the Atrioventricular Crossroads: Dual Pathway Electrophysiology in the Atrioventricular Node and its Underlying Heterogeneities. Arrhythmia & Electrophysiology Review, 6(4), 179–185. https://doi.org/10.15420/aer.2017.30.1
George, Sharon A., N Rokhaya Faye, Alejandro Murillo-Berlioz, K Benjamin Lee, Gregory D. Trachiotis, and Igor R. Efimov. “At the Atrioventricular Crossroads: Dual Pathway Electrophysiology in the Atrioventricular Node and its Underlying Heterogeneities.Arrhythmia & Electrophysiology Review 6, no. 4 (December 2017): 179–85. https://doi.org/10.15420/aer.2017.30.1.
George SA, Faye NR, Murillo-Berlioz A, Lee KB, Trachiotis GD, Efimov IR. At the Atrioventricular Crossroads: Dual Pathway Electrophysiology in the Atrioventricular Node and its Underlying Heterogeneities. Arrhythmia & electrophysiology review. 2017 Dec;6(4):179–85.
George, Sharon A., et al. “At the Atrioventricular Crossroads: Dual Pathway Electrophysiology in the Atrioventricular Node and its Underlying Heterogeneities.Arrhythmia & Electrophysiology Review, vol. 6, no. 4, Dec. 2017, pp. 179–85. Epmc, doi:10.15420/aer.2017.30.1.
George SA, Faye NR, Murillo-Berlioz A, Lee KB, Trachiotis GD, Efimov IR. At the Atrioventricular Crossroads: Dual Pathway Electrophysiology in the Atrioventricular Node and its Underlying Heterogeneities. Arrhythmia & electrophysiology review. 2017 Dec;6(4):179–185.

Published In

Arrhythmia & electrophysiology review

DOI

EISSN

2050-3377

ISSN

2050-3369

Publication Date

December 2017

Volume

6

Issue

4

Start / End Page

179 / 185