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Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry.

Publication ,  Journal Article
Bennett, MC; Patel, A; Sainani, N; Wang, D; Sayuk, GS; Gyawali, CP
Published in: J Neurogastroenterol Motil
July 30, 2018

BACKGROUND/AIMS: Breaks in the peristaltic contour on esophageal high-resolution manometry (HRM) may be associated with bolus retention in the esophagus. We evaluated the relationship between peristaltic breaks and esophageal symptoms, reflux exposure, and symptom outcomes in a prospective patient cohort. METHODS: Two hundred and eighteen patients (53.2 ± 0.9 years, 68.3% female) undergoing both pH-impedance testing and HRM over a 5-year period were prospectively evaluated. Demographics, symptom presentation, acid exposure time, symptom association probability, and symptom burden scores were collected. Outcomes were assessed on follow-up using changes in symptom scores. Presence of long breaks (≥ 5 cm) on HRM was assessed by a blinded author. Relationships between breaks, reflux parameters, presenting symptoms, and outcomes were assessed. RESULTS: Patients with long breaks were more likely to have cough as a presenting symptom than those without (43.4% vs 28.6%, P = 0.024); statistical differences were not demonstrated with other symptoms (P ≥ 0.3). Numbers of swallows with long breaks were higher in patients with cough compared to those without (2.4 ± 0.3 vs 1.6 ± 0.2, P = 0.021); differences were not found with other symptoms (P ≥ 0.4). Long breaks were not associated with age, gender, race, reflux burden, symptom association, or changes in symptom metrics (P ≥ 0.1 for all comparisons). Among patients with cough, the presence of long breaks predicted suboptimal symptom improvement with antireflux therapy (P = 0.018); this difference did not hold true for other symptoms (P ≥ 0.2). CONCLUSIONS: Long breaks in esophageal peristaltic integrity are associated with cough. The presence of long breaks is associated with suboptimal benefit from antireflux therapy.

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Published In

J Neurogastroenterol Motil

DOI

ISSN

2093-0879

Publication Date

July 30, 2018

Volume

24

Issue

3

Start / End Page

387 / 394

Location

Korea (South)

Related Subject Headings

  • 3202 Clinical sciences
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bennett, M. C., Patel, A., Sainani, N., Wang, D., Sayuk, G. S., & Gyawali, C. P. (2018). Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry. J Neurogastroenterol Motil, 24(3), 387–394. https://doi.org/10.5056/jnm17126
Bennett, Michael C., Amit Patel, Nitin Sainani, Dan Wang, Gregory S. Sayuk, and C Prakash Gyawali. “Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry.J Neurogastroenterol Motil 24, no. 3 (July 30, 2018): 387–94. https://doi.org/10.5056/jnm17126.
Bennett MC, Patel A, Sainani N, Wang D, Sayuk GS, Gyawali CP. Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry. J Neurogastroenterol Motil. 2018 Jul 30;24(3):387–94.
Bennett, Michael C., et al. “Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry.J Neurogastroenterol Motil, vol. 24, no. 3, July 2018, pp. 387–94. Pubmed, doi:10.5056/jnm17126.
Bennett MC, Patel A, Sainani N, Wang D, Sayuk GS, Gyawali CP. Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry. J Neurogastroenterol Motil. 2018 Jul 30;24(3):387–394.

Published In

J Neurogastroenterol Motil

DOI

ISSN

2093-0879

Publication Date

July 30, 2018

Volume

24

Issue

3

Start / End Page

387 / 394

Location

Korea (South)

Related Subject Headings

  • 3202 Clinical sciences
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics