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Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.

Publication ,  Journal Article
Naggie, S; Swiderska-Syn, M; Choi, S; Lusk, S; Lan, A; Ferrari, G; Syn, W-K; Guy, CD; Diehl, AM
Published in: Open Forum Infect Dis
July 2018

Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)-related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin-embedded liver tissue for HIV-infected patients, HCV-infected patients, HIV/HCV-coinfected patients, and controls at Duke University Medical Center. De-identified sections were stained for markers against the wound repair Hedgehog (Hh) pathway, resident T-lymphocytes, and immune activation and cellular aging. HIV infection was independently associated with Hh activation and markers of immune dysregulation in the liver tissue.

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Published In

Open Forum Infect Dis

DOI

ISSN

2328-8957

Publication Date

July 2018

Volume

5

Issue

7

Start / End Page

ofy138

Location

United States

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

Citation

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Chicago
ICMJE
MLA
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Naggie, S., Swiderska-Syn, M., Choi, S., Lusk, S., Lan, A., Ferrari, G., … Diehl, A. M. (2018). Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection. Open Forum Infect Dis, 5(7), ofy138. https://doi.org/10.1093/ofid/ofy138
Naggie, Susanna, Marzena Swiderska-Syn, Steve Choi, Sam Lusk, Audrey Lan, Guido Ferrari, Wing-Kin Syn, Cynthia D. Guy, and Anna Mae Diehl. “Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.Open Forum Infect Dis 5, no. 7 (July 2018): ofy138. https://doi.org/10.1093/ofid/ofy138.
Naggie S, Swiderska-Syn M, Choi S, Lusk S, Lan A, Ferrari G, et al. Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection. Open Forum Infect Dis. 2018 Jul;5(7):ofy138.
Naggie, Susanna, et al. “Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.Open Forum Infect Dis, vol. 5, no. 7, July 2018, p. ofy138. Pubmed, doi:10.1093/ofid/ofy138.
Naggie S, Swiderska-Syn M, Choi S, Lusk S, Lan A, Ferrari G, Syn W-K, Guy CD, Diehl AM. Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection. Open Forum Infect Dis. 2018 Jul;5(7):ofy138.
Journal cover image

Published In

Open Forum Infect Dis

DOI

ISSN

2328-8957

Publication Date

July 2018

Volume

5

Issue

7

Start / End Page

ofy138

Location

United States

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences